Environmental and Genetic Factors Affecting Transport of Imatinib by OATP1A2

The bioavailability of orally administered imatinib is >90%, although the drug is monocationic under the acidic conditions in the duodenum. In vitro, we found that imatinib is transported by the intestinal uptake carrier organic anion transporting polypeptide (OATP1A2) and that this process is se...

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Bibliographic Details
Published in:	Clinical pharmacology and therapeutics Vol. 89; no. 6; pp. 816 - 820
Main Authors:	Eechoute, K, Franke, RM, Loos, WJ, Scherkenbach, LA, Boere, I, Verweij, J, Gurney, H, Kim, RB, Tirona, RG, Mathijssen, RHJ, Sparreboom, A
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-06-2011
Subjects:	Animals Benzamides Biological and medical sciences Biological Transport, Active - physiology Environment Environment. Living conditions Female HeLa Cells Humans Imatinib Mesylate Medical sciences Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Pharmacology. Drug treatments Piperazines - antagonists & inhibitors Piperazines - metabolism Public health. Hygiene Public health. Hygiene-occupational medicine Pyrimidines - antagonists & inhibitors Pyrimidines - metabolism Xenopus laevis Antineoplastic agent Human Imatinib Health and environment Enzyme Tyrosine kinase inhibitor Transferases Enzyme inhibitor Environmental factor Transport Protein-tyrosine kinase Genetic determinism
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