High-fat diet with acyl-ghrelin treatment leads to weight gain with low inflammation, high oxidative capacity and normal triglycerides in rat muscle

Obesity is associated with muscle lipid accumulation. Experimental models suggest that inflammatory cytokines, low mitochondrial oxidative capacity and paradoxically high insulin signaling activation favor this alteration. The gastric orexigenic hormone acylated ghrelin (A-Ghr) has antiinflammatory...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 10; p. e26224
Main Authors:	Barazzoni, Rocco, Zanetti, Michela, Semolic, Annamaria, Cattin, Maria Rosa, Pirulli, Alessia, Cattin, Luigi, Guarnieri, Gianfranco
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 19-10-2011 Public Library of Science (PLoS)
Subjects:	Accumulation AKT protein Animal models Animals Antioxidants Biology Body weight Body weight gain Cytokines Cytotoxicity Diabetes Diet Dietary Fats - administration & dosage Endocrinology Enzymes Fatty acids Feeding Ghrelin Ghrelin - pharmacology Ghrelin - therapeutic use Glucose Glutathione Glutathione peroxidase Glutathione Peroxidase - metabolism Growth hormones Health sciences High fat diet Inflammation Inflammation - prevention & control Insulin Insulin resistance Lipids Male Medicine Metabolism Mitochondria Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism Musculoskeletal system NF-κB protein Obesity Oils & fats Oxidative Stress Pathogenesis Peroxidase Phosphorylation Plasma Rats Rats, Wistar Redox properties Respiration Rodents Signaling Skeletal muscle Systems analysis Thiobarbituric Acid Reactive Substances - metabolism Triglycerides Triglycerides - metabolism Tumor necrosis factor-α Weight Gain - drug effects
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