The establishment of resident memory B cells in the lung requires local antigen encounter

Memory B cells are found in lymphoid and non-lymphoid tissues, suggesting that some may be tissue-resident cells. Here we show that pulmonary influenza infection elicited lung-resident memory B cells (BRM cells) that were phenotypically and functionally distinct from their systemic counterparts. BRM...

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Bibliographic Details
Published in:	Nature immunology Vol. 20; no. 1; pp. 97 - 108
Main Authors:	Allie, S. Rameeza, Bradley, John E., Mudunuru, Uma, Schultz, Michael D., Graf, Beth A., Lund, Frances E., Randall, Troy D.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-01-2019 Nature Publishing Group
Subjects:	631/250/1619/40 631/250/2152 631/250/255 631/250/347 Animals Antigens Antigens, Viral - immunology B cells B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine Cell Differentiation Cells, Cultured Cellular signal transduction Computer memory Female Gene expression Humans Immunity, Humoral Immunologic Memory Immunological memory Immunology Infection Infections Infectious Diseases Influenza Influenza vaccines Influenza Vaccines - immunology Influenza viruses Influenza, Human - immunology Lung Lung - immunology Lung - virology Lung diseases Lungs Lymphocyte Activation Lymphocytes B Lymphoid tissue Male Memory cells Mice Mice, Inbred C57BL Mice, Transgenic Orthomyxoviridae - physiology Orthomyxoviridae Infections - immunology Plasma Cells - immunology Secondary infection
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