Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at l...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; p. 105
Main Authors:	Fellows, Rachel, Denizot, Jérémy, Stellato, Claudia, Cuomo, Alessandro, Jain, Payal, Stoyanova, Elena, Balázsi, Szabina, Hajnády, Zoltán, Liebert, Anke, Kazakevych, Juri, Blackburn, Hector, Corrêa, Renan Oliveira, Fachi, José Luís, Sato, Fabio Takeo, Ribeiro, Willian R., Ferreira, Caroline Marcantonio, Perée, Hélène, Spagnuolo, Mariangela, Mattiuz, Raphaël, Matolcsi, Csaba, Guedes, Joana, Clark, Jonathan, Veldhoen, Marc, Bonaldi, Tiziana, Vinolo, Marco Aurélio Ramirez, Varga-Weisz, Patrick
Format:	Journal Article Web Resource
Language:	English
Published:	London Nature Publishing Group UK 09-01-2018 Nature Publishing Group Nature Portfolio
Subjects:	13 13/1 13/106 13/109 13/51 38 38/23 42 631/208/199 631/337/100/1701 631/337/100/2285 631/443/319/320 64 64/60 82/29 Acylation Animal genetics Animals Biochemistry, Molecular Biology Cell Cycle Chains Chromatin Colon Colon - metabolism Colon - microbiology Crotonates - metabolism Digestive system Fatty acids Fatty Acids, Volatile - physiology Gastrointestinal Microbiome Gastrointestinal tract Gene expression Gene regulation Genetics Genetics & genetic processes Genomics Génétique & processus génétiques HCT116 Cells HDAC2 protein Histone deacetylase Histone Deacetylase Inhibitors Histone Deacetylases - metabolism Histone H3 Histones - metabolism Humanities and Social Sciences Humans Intestinal microflora Intestinal Mucosa - metabolism Life Sciences Lysine Male Metabolism Mice, Inbred C57BL Microbiota Molecular biology multidisciplinary Post-translation Protein Processing, Post-Translational Science Science (multidisciplinary) Sciences du vivant Small intestine
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