Characterization and Activation of NLRP3 Inflammasomes in the Renal Medulla in Mice

Abstract Background/Aims: Recent studies have indicated that local inflammatory mediators are importantly involved in the regulation of renal function. However, it remains unknown how such local inflammation is triggered intracellularly in the kidney. The present study was designed to characterize t...

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Bibliographic Details
Published in:	Kidney & blood pressure research Vol. 41; no. 2; pp. 208 - 221
Main Authors:	Xia, Min, Abais, Justine M., Koka, Saisudha, Meng, Nan, Gehr, Todd W., Boini, Krishna M., Li, Pin-Lan
Format:	Journal Article
Language:	English
Published:	Basel, Switzerland S. Karger AG 01-03-2016 Karger Publishers
Subjects:	Alzheimer's disease Animals Blood flow Blood Flow Velocity Blood pressure Caspase-1 Catheters Cellular inflammation Confocal microscopy Dissection Excretion Gene Deletion Hemodynamics Immunohistochemistry Inflammasomes Inflammasomes - genetics Inflammasomes - metabolism Inflammation Inflammatory mediators Inflammatory response Kidney diseases Kidney Medulla - blood supply Kidney Medulla - metabolism Kidney Medulla - pathology Kidneys Male Mice Mice, Inbred C57BL Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Original Paper Ostomy Regulatory mechanisms (biology) Renal function Renal medulla Rheumatism Sodium Uric acid Urinary excretion Cellular inflammation Renal medulla Uric acid Inflammatory mediators Urinary excretion
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