Adenovirus-mediated delivery of CD46 attenuates the alternative complement pathway on RPE: implications for age-related macular degeneration

Activation of the alternative pathway of the complement system has been implicated in the pathogenesis of age-related macular degeneration. Membrane attack complex (MAC) has been identified mainly on the Bruch's membrane and drusen underlying the retinal pigment epithelium (RPE). Membrane cofac...

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Bibliographic Details
Published in:	Gene therapy Vol. 18; no. 6; pp. 613 - 621
Main Authors:	Sweigard, J H, Cashman, S M, Kumar-Singh, R
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-06-2011 Nature Publishing Group
Subjects:	631/250/2501 631/326/596/2561 631/378/1689/1626 631/61/2300 Adenoviridae - genetics Adenovirus Adenoviruses Adult Age Alternative pathway Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Care and treatment CD46 antigen Cell Biology Cell Line Classical pathway Complement activation Complement Membrane Attack Complex - metabolism Complement Pathway, Alternative - genetics Complement Pathway, Alternative - immunology Complement system Epithelium Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Genetic Therapy Genetic transformation Genetic Vectors Health. Pharmaceutical industry Hepatocytes Hepatocytes - metabolism Human Genetics Humans Industrial applications and implications. Economical aspects Lysis Macular degeneration Macular Degeneration - genetics Macular Degeneration - immunology Medical sciences Membrane attack complex Membrane cofactor protein Membrane Cofactor Protein - genetics Membrane Cofactor Protein - pharmacology Membrane proteins Mice Nanotechnology original-article Retina - embryology Retina - metabolism Retinal pigment epithelium Retinal Pigment Epithelium - immunology Retinal Pigment Epithelium - metabolism Rodents Transfusions. Complications. Transfusion reactions. Cell and gene therapy United States CD46 age-related macular degeneration adenovirus Virus Eye disease Retinopathy Adenoviridae Alternative pathway complement Age related macular degeneration Gene therapy Vector
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