Androgens Prevent Normally Occurring Cell Death in a Sexually Dimorphic Spinal Nucleus
The spinal nucleus of the bulbocavernosus (SNB) contains many more motoneurons in adult male rats than in females. Androgens establish this sex difference during a critical perinatal period, which coincides with normally occurring cell death in the SNB region. Sex differences in SNB motoneuron numbe...
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| Published in: | Science (American Association for the Advancement of Science) Vol. 229; no. 4714; pp. 671 - 673 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
The American Association for the Advancement of Science
16-08-1985
American Association for the Advancement of Science |
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| Abstract | The spinal nucleus of the bulbocavernosus (SNB) contains many more motoneurons in adult male rats than in females. Androgens establish this sex difference during a critical perinatal period, which coincides with normally occurring cell death in the SNB region. Sex differences in SNB motoneuron number arise primarily because motoneuron loss is greater in females than in males during the early postnatal period. Perinatal androgen treatment in females attenuates cell death in the SNB region, reducing motoneuron loss to levels typical of males. The results suggest that steroid hormones determine sex differences in neuron number by regulating normally occurring cell death and that the timing of this cell death may therefore define critical periods for steroid effects on neuron number. |
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| AbstractList | The spinal nucleus of the bulbocavernosus (SNB) contains many more motoneurons in adult male rats than in females. Androgens establish this sex difference during a critical perinatal period, which coincides with normally occurring cell death in the SNB region. Sex differences in SNB motoneuron number arise primarily because motoneuron loss is greater in females than in males during the early postnatal period. Perinatal androgen treatment in females attenuates cell death in the SNB region, reducing motoneuron loss to levels typical of males. The results suggest that steroid hormones determine sex differences in neuron number by regulating normally occurring cell death and that the timing of this cell death may therefore define critical periods for steroid effects on neuron number. The spinal nucleus of the bulbocavernosus (SNB) contains many more motoneurons in adult male rats than in females. Androgens establish this sex difference during a critical perinatal period, which coincides with normally occurring cell death in the SNB region. Sex differences in SNB motoneuron number arise primarily because motoneuron loss is greater in females than in males during the early postnatal period. Perinatal androgen treatment in females attenuates cell death in the SNB region, reducing motoneuron loss to levels typical of males. |
| Audience | Academic |
| Author | Nordeen, E. J. Sengelaub, D. R. Arnold, A. P. Nordeen, K. W. |
| Author_xml | – sequence: 1 givenname: E. J. surname: Nordeen fullname: Nordeen, E. J. – sequence: 2 givenname: K. W. surname: Nordeen fullname: Nordeen, K. W. – sequence: 3 givenname: D. R. surname: Sengelaub fullname: Sengelaub, D. R. – sequence: 4 givenname: A. P. surname: Arnold fullname: Arnold, A. P. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/4023706$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright 1985 The American Association for the Advancement of Science COPYRIGHT 1985 American Association for the Advancement of Science COPYRIGHT 1985 American Association for the Advancement of Science |
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| References | (e_1_2_1_16_1) 1976; 71 (e_1_2_1_3_1) 1983; 3 (e_1_2_1_8_1) 1976; 54 (e_1_2_1_11_1) 1983; 31 (e_1_2_1_7_1) 1970; 106 (e_1_2_1_1_1) 1984; 7 (e_1_2_1_2_1) 1983; 9 (e_1_2_1_14_1) 1984; 10 (e_1_2_1_19_1) 1982; 204 (e_1_2_1_10_1) 1984; 4 (e_1_2_1_6_1) 1984; 10 (e_1_2_1_15_1) 1981 (e_1_2_1_18_1) 1983; 52 (e_1_2_1_17_1) 1978 e_1_2_1_5_1 (e_1_2_1_4_1) 1983; 3 e_1_2_1_12_1 (e_1_2_1_13_1) 1970 (e_1_2_1_20_1) 1984; 10 (e_1_2_1_21_1) 1980; 106 e_1_2_1_9_1 |
| References_xml | – volume: 3 start-page: 424 year: 1983 ident: e_1_2_1_4_1 publication-title: JOURNAL OF NEUROSCIENCE doi: 10.1523/JNEUROSCI.03-02-00424.1983 – ident: e_1_2_1_9_1 doi: 10.1126/science.6828866 – volume: 71 start-page: 231 year: 1976 ident: e_1_2_1_16_1 publication-title: JOURNAL OF ENDOCRINOLOGY doi: 10.1677/joe.0.0710231 – volume: 31 start-page: 807 year: 1983 ident: e_1_2_1_11_1 publication-title: PHYSIOLOGY AND BEHAVIOR doi: 10.1016/0031-9384(83)90277-9 – volume: 106 start-page: 93 year: 1970 ident: e_1_2_1_7_1 publication-title: JOURNAL OF ANATOMY – volume: 4 start-page: 767 year: 1984 ident: e_1_2_1_10_1 publication-title: JOURNAL OF NEUROSCIENCE doi: 10.1523/JNEUROSCI.04-03-00767.1984 – volume: 204 start-page: 311 year: 1982 ident: e_1_2_1_19_1 publication-title: JOURNAL OF COMPARATIVE NEUROLOGY doi: 10.1002/cne.902040402 – volume: 54 start-page: 50 year: 1976 ident: e_1_2_1_8_1 publication-title: CANADIAN JOURNAL OF BIOCHEMISTRY doi: 10.1139/o76-008 – volume: 106 start-page: 306 year: 1980 ident: e_1_2_1_21_1 publication-title: ENDOCRINOLOGY doi: 10.1210/endo-106-1-306 – volume: 10 start-page: 453 year: 1984 ident: e_1_2_1_20_1 publication-title: SOCIETY FOR NEUROSCIENCE. ABSTRACTS – volume: 7 start-page: 413 year: 1984 ident: e_1_2_1_1_1 publication-title: ANNUAL REVIEW OF NEUROSCIENCE doi: 10.1146/annurev.ne.07.030184.002213 – volume: 10 start-page: 927 year: 1984 ident: e_1_2_1_6_1 publication-title: SOCIETY FOR NEUROSCIENCE. ABSTRACTS – start-page: 74 year: 1981 ident: e_1_2_1_15_1 publication-title: Studies in Developmental Neurobiology – volume: 9 start-page: 39 year: 1983 ident: e_1_2_1_2_1 publication-title: DEVELOPMENTAL BRAIN RESEARCH doi: 10.1016/0165-3806(83)90106-2 – start-page: 153 year: 1978 ident: e_1_2_1_17_1 publication-title: Biological Determinant of Sexual Behavior – volume: 3 start-page: 417 year: 1983 ident: e_1_2_1_3_1 publication-title: JOURNAL OF NEUROSCIENCE doi: 10.1523/JNEUROSCI.03-02-00417.1983 – ident: e_1_2_1_5_1 doi: 10.1126/science.7423210 – ident: e_1_2_1_12_1 doi: 10.1007/978-1-4757-4951-9 – start-page: 315 year: 1970 ident: e_1_2_1_13_1 publication-title: Contemporary Research Methods in Neuroanatomy – volume: 52 start-page: 269 year: 1983 ident: e_1_2_1_18_1 publication-title: EXPERIMENTAL BRAIN RESEARCH – volume: 10 start-page: 902 year: 1984 ident: e_1_2_1_14_1 publication-title: SOCIETY FOR NEUROSCIENCE. ABSTRACTS |
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| Snippet | The spinal nucleus of the bulbocavernosus (SNB) contains many more motoneurons in adult male rats than in females. Androgens establish this sex difference... |
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| SubjectTerms | Adulthood Androgens Androgens - pharmacology Animals Axons Cell death Cell Survival - drug effects Critical periods development Female Male Mating behavior Motor neurons Motor Neurons - physiology Neuroendocrinology Neurons Penis - innervation Physiological aspects Physiological regulation Rats Rattus Reproduction Sex Characteristics sex differences Sex linked differences spinal cord |
| Title | Androgens Prevent Normally Occurring Cell Death in a Sexually Dimorphic Spinal Nucleus |
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