Microbubbles combined with ultrasound therapy in ischemic stroke: A systematic review of in-vivo preclinical studies
Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical results remain controversial. The aim of this systematic review is to identify the parameters tested; to assess evidence on the safety and...
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| Published in: | PloS one Vol. 13; no. 2; p. e0191788 |
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08-02-2018
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| Abstract | Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical results remain controversial.
The aim of this systematic review is to identify the parameters tested; to assess evidence on the safety and efficacy on preclinical data on STL; and to assess the validity and publication bias.
Pubmed® and Web of ScienceTM databases were systematically searched from January 1995 to April 2017 in French and English. We included studies evaluating STL on animal stroke model. This systematic review was conducted in accordance with the PRISMA guidelines. Data were extracted following a pre-defined schedule by two of the authors. The CAMARADES criteria were used for quality assessment. A narrative synthesis was conducted.
Sixteen studies met the inclusion criteria. The result showed that ultrasound parameters and types of MBs were heterogeneous among studies. Numerous positive outcomes on efficacy were found, but only four studies demonstrated superiority of STL versus recombinant tissue-type plasminogen activator on clinical criteria. Data available on safety are limited.
Quality assessment of the studies reviewed revealed a number of biases.
Further in vivo studies are needed to demonstrate a better efficacy and safety of STL compared to currently approved therapeutic options.
http://syrf.org.uk/protocols/. |
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| AbstractList | Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical results remain controversial. The aim of this systematic review is to identify the parameters tested; to assess evidence on the safety and efficacy on preclinical data on STL; and to assess the validity and publication bias. Pubmed.sup.® and Web of Science.sup.TM databases were systematically searched from January 1995 to April 2017 in French and English. We included studies evaluating STL on animal stroke model. This systematic review was conducted in accordance with the PRISMA guidelines. Data were extracted following a pre-defined schedule by two of the authors. The CAMARADES criteria were used for quality assessment. A narrative synthesis was conducted. Sixteen studies met the inclusion criteria. The result showed that ultrasound parameters and types of MBs were heterogeneous among studies. Numerous positive outcomes on efficacy were found, but only four studies demonstrated superiority of STL versus recombinant tissue-type plasminogen activator on clinical criteria. Data available on safety are limited. Further in vivo studies are needed to demonstrate a better efficacy and safety of STL compared to currently approved therapeutic options. http://syrf.org.uk/protocols/ Background Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical results remain controversial. Objective The aim of this systematic review is to identify the parameters tested; to assess evidence on the safety and efficacy on preclinical data on STL; and to assess the validity and publication bias. Methods Pubmed.sup.® and Web of Science.sup.TM databases were systematically searched from January 1995 to April 2017 in French and English. We included studies evaluating STL on animal stroke model. This systematic review was conducted in accordance with the PRISMA guidelines. Data were extracted following a pre-defined schedule by two of the authors. The CAMARADES criteria were used for quality assessment. A narrative synthesis was conducted. Results Sixteen studies met the inclusion criteria. The result showed that ultrasound parameters and types of MBs were heterogeneous among studies. Numerous positive outcomes on efficacy were found, but only four studies demonstrated superiority of STL versus recombinant tissue-type plasminogen activator on clinical criteria. Data available on safety are limited. Limitations Quality assessment of the studies reviewed revealed a number of biases. Conclusion Further in vivo studies are needed to demonstrate a better efficacy and safety of STL compared to currently approved therapeutic options. Systematic review registration Background: Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical results remain controversial.Objective: The aim of this systematic review is to identify the parameters tested; to assess evidence on the safety and efficacy on preclinical data on STL; and to assess the validity and publication bias.Methods: Pubmed® and Web of ScienceTM databases were systematically searched from January 1995 to April 2017 in French and English. We included studies evaluating STL on animal stroke model. This systematic review was conducted in accordance with the PRISMA guidelines. Data were extracted following a pre-defined schedule by two of the authors. The CAMARADES criteria were used for quality assessment. A narrative synthesis was conducted.Results: Sixteen studies met the inclusion criteria. The result showed that ultrasound parameters and types of MBs were heterogeneous among studies. Numerous positive outcomes on efficacy were found, but only four studies demonstrated superiority of STL versus recombinant tissue-type plasminogen activator on clinical criteria. Data available on safety are limited.Limitations: Quality assessment of the studies reviewed revealed a number of biases.Conclusion: Further in vivo studies are needed to demonstrate a better efficacy and safety of STL compared to currently approved therapeutic options. Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical results remain controversial. The aim of this systematic review is to identify the parameters tested; to assess evidence on the safety and efficacy on preclinical data on STL; and to assess the validity and publication bias. Pubmed® and Web of ScienceTM databases were systematically searched from January 1995 to April 2017 in French and English. We included studies evaluating STL on animal stroke model. This systematic review was conducted in accordance with the PRISMA guidelines. Data were extracted following a pre-defined schedule by two of the authors. The CAMARADES criteria were used for quality assessment. A narrative synthesis was conducted. Sixteen studies met the inclusion criteria. The result showed that ultrasound parameters and types of MBs were heterogeneous among studies. Numerous positive outcomes on efficacy were found, but only four studies demonstrated superiority of STL versus recombinant tissue-type plasminogen activator on clinical criteria. Data available on safety are limited. Quality assessment of the studies reviewed revealed a number of biases. Further in vivo studies are needed to demonstrate a better efficacy and safety of STL compared to currently approved therapeutic options. http://syrf.org.uk/protocols/. BACKGROUNDMicrobubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical results remain controversial.OBJECTIVEThe aim of this systematic review is to identify the parameters tested; to assess evidence on the safety and efficacy on preclinical data on STL; and to assess the validity and publication bias.METHODSPubmed® and Web of ScienceTM databases were systematically searched from January 1995 to April 2017 in French and English. We included studies evaluating STL on animal stroke model. This systematic review was conducted in accordance with the PRISMA guidelines. Data were extracted following a pre-defined schedule by two of the authors. The CAMARADES criteria were used for quality assessment. A narrative synthesis was conducted.RESULTSSixteen studies met the inclusion criteria. The result showed that ultrasound parameters and types of MBs were heterogeneous among studies. Numerous positive outcomes on efficacy were found, but only four studies demonstrated superiority of STL versus recombinant tissue-type plasminogen activator on clinical criteria. Data available on safety are limited.LIMITATIONSQuality assessment of the studies reviewed revealed a number of biases.CONCLUSIONFurther in vivo studies are needed to demonstrate a better efficacy and safety of STL compared to currently approved therapeutic options.SYSTEMATIC REVIEW REGISTRATIONhttp://syrf.org.uk/protocols/. Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical results remain controversial.The aim of this systematic review is to identify the parameters tested; to assess evidence on the safety and efficacy on preclinical data on STL; and to assess the validity and publication bias.Pubmed® and Web of ScienceTM databases were systematically searched from January 1995 to April 2017 in French and English. We included studies evaluating STL on animal stroke model. This systematic review was conducted in accordance with the PRISMA guidelines. Data were extracted following a pre-defined schedule by two of the authors. The CAMARADES criteria were used for quality assessment. A narrative synthesis was conducted.Sixteen studies met the inclusion criteria. The result showed that ultrasound parameters and types of MBs were heterogeneous among studies. Numerous positive outcomes on efficacy were found, but only four studies demonstrated superiority of STL versus recombinant tissue-type plasminogen activator on clinical criteria. Data available on safety are limited.Quality assessment of the studies reviewed revealed a number of biases.Further in vivo studies are needed to demonstrate a better efficacy and safety of STL compared to currently approved therapeutic options.http://syrf.org.uk/protocols/. |
| Audience | Academic |
| Author | Sennoga, Charles A Tranquart, François Bouakaz, Ayache Hyvelin, Jean-Marc Ossant, Fréderic Escoffre, Jean-Michel Auboire, Laurent |
| AuthorAffiliation | 4 CHRU de Tours, CIC-IT, Tours, France 5 Advice-US Consulting, Nernier, France 2 CHRU de Tours, Service d’échographie-Doppler, Tours, France 1 UMR Imagerie et Cerveau, Inserm U930, Université François-Rabelais de Tours, France 3 Bracco Suisse SA, Geneva, Switzerland Cedars-Sinai Medical Center, UNITED STATES |
| AuthorAffiliation_xml | – name: 3 Bracco Suisse SA, Geneva, Switzerland – name: 5 Advice-US Consulting, Nernier, France – name: 1 UMR Imagerie et Cerveau, Inserm U930, Université François-Rabelais de Tours, France – name: 4 CHRU de Tours, CIC-IT, Tours, France – name: Cedars-Sinai Medical Center, UNITED STATES – name: 2 CHRU de Tours, Service d’échographie-Doppler, Tours, France |
| Author_xml | – sequence: 1 givenname: Laurent orcidid: 0000-0002-7379-8506 surname: Auboire fullname: Auboire, Laurent organization: CHRU de Tours, Service d'échographie-Doppler, Tours, France – sequence: 2 givenname: Charles A surname: Sennoga fullname: Sennoga, Charles A organization: UMR Imagerie et Cerveau, Inserm U930, Université François-Rabelais de Tours, France – sequence: 3 givenname: Jean-Marc surname: Hyvelin fullname: Hyvelin, Jean-Marc organization: Bracco Suisse SA, Geneva, Switzerland – sequence: 4 givenname: Fréderic surname: Ossant fullname: Ossant, Fréderic organization: CHRU de Tours, CIC-IT, Tours, France – sequence: 5 givenname: Jean-Michel surname: Escoffre fullname: Escoffre, Jean-Michel organization: UMR Imagerie et Cerveau, Inserm U930, Université François-Rabelais de Tours, France – sequence: 6 givenname: François surname: Tranquart fullname: Tranquart, François organization: Advice-US Consulting, Nernier, France – sequence: 7 givenname: Ayache surname: Bouakaz fullname: Bouakaz, Ayache organization: UMR Imagerie et Cerveau, Inserm U930, Université François-Rabelais de Tours, France |
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| DocumentTitleAlternate | Sonothrombolysis with microbubbles in ischemic stroke - an assessment of pre-clinical evidence |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Undefined-4 Competing Interests: Bracco Suisse SA provided support in the form of salaries for author [JMH], Advice-US consulting provided support in the form of salaries for author [FT]. Bracco Suisse SA and Advice-US consulting did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This does not alter our adherence to PLOS ONE policies on sharing data and materials. |
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publication-title: Trends Neurosci doi: 10.1016/j.tins.2007.06.009 contributor: fullname: E Sena |
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| Snippet | Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but... Background Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS),... BACKGROUNDMicrobubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS),... Background: Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke... |
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| Title | Microbubbles combined with ultrasound therapy in ischemic stroke: A systematic review of in-vivo preclinical studies |
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