(2S)-2′-Methoxykurarinone Inhibits Osteoclastogenesis and Bone Resorption through Down-Regulation of RANKL Signaling

(2S)-2′-Methoxykurarinone (MK), a compound isolated from the roots of Sophora flavescens, has various physiological properties, such as anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. However, the effect of S. flavescens-derived MK on osteoclastogenesis remains unknown. The...

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Bibliographic Details
Published in:	Biological & pharmaceutical bulletin Vol. 37; no. 2; pp. 255 - 261
Main Authors:	Kim, Ju-Young, Kim, Jung Young, Kim, Jeong Joong, Oh, Jaemin, Kim, Youn-Chul, Lee, Myeung Su
Format:	Journal Article
Language:	English
Published:	Japan The Pharmaceutical Society of Japan 01-02-2014 Pharmaceutical Society of Japan
Subjects:	(2S)-2′-methoxykurarinone Animals Bone Marrow Cells - drug effects bone resorption Bone Resorption - metabolism Bone Resorption - prevention & control Cell Differentiation - drug effects Down-Regulation Flavonoids - pharmacology Flavonoids - therapeutic use Humans Macrophages - drug effects Mice Mice, Inbred ICR Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism NFATC Transcription Factors - metabolism Osteoblasts - metabolism osteoclast Osteoclasts - drug effects Osteoclasts - metabolism Osteoclasts - physiology osteoporosis Osteoprotegerin - metabolism Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Proto-Oncogene Proteins c-fos - metabolism RANK Ligand - metabolism Receptor Activator of Nuclear Factor-kappa B - metabolism receptor activator of nuclear factor-κB ligand (RANKL) Signal Transduction Sophora - chemistry
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