Comparative Study of Novel Ultradeformable Liposomes: Menthosomes, Transfersomes and Liposomes for Enhancing Skin Permeation of Meloxicam

In the present study, novel ultradeformable liposomes (menthosomes; MTS), deformable liposomes (transfersomes; TFS) and conventional liposomes (CLP) were compared in their potential for transdermal delivery of meloxicam (MX). MTS, TFS and CLP were investigated for size, size distribution, zeta poten...

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Published in:	Biological & pharmaceutical bulletin Vol. 37; no. 2; pp. 239 - 247
Main Authors:	Duangjit, Sureewan, Obata, Yasuko, Sano, Hiromu, Onuki, Yoshinori, Opanasopit, Praneet, Ngawhirunpat, Tanasait, Miyoshi, Tsubasa, Kato, Satoru, Takayama, Kozo
Format:	Journal Article
Language:	English
Published:	Japan The Pharmaceutical Society of Japan 01-02-2014 Pharmaceutical Society of Japan
Subjects:	Administration, Cutaneous Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Drug Carriers - chemistry liposome Liposomes Male Meloxicam menthol menthosome Mice Mice, Hairless Permeability Skin - metabolism Skin Absorption skin permeation Thiazines - administration & dosage Thiazines - pharmacokinetics Thiazoles - administration & dosage Thiazoles - pharmacokinetics transfersome
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Abstract	In the present study, novel ultradeformable liposomes (menthosomes; MTS), deformable liposomes (transfersomes; TFS) and conventional liposomes (CLP) were compared in their potential for transdermal delivery of meloxicam (MX). MTS, TFS and CLP were investigated for size, size distribution, zeta potential, elasticity, entrapment efficiency and stability. In vitro skin permeation using hairless mice skin was evaluated. Vesicular morphology was observed under freeze-fractured transmission electron microscopy (FF-TEM). Intrinsic thermal properties were performed using differential scanning calorimetry (DSC) and X-ray diffraction. The skin permeation mechanism was characterized using confocal laser scanning microscopy (CLSM). The results indicated that the difference in physicochemical characteristics of MTS, TFS and CLP affected the skin permeability. MTS and TFS showed higher flux of MX than CLP. CLSM image showed deformable vesicles mechanism for delivery of MX across the hairless mice skin. Our study suggested that ultradeformable and deformable liposomes (MTS and TFS) had a potential to use as transdermal drug delivery carriers for MX.
AbstractList	In the present study, novel ultradeformable liposomes (menthosomes; MTS), deformable liposomes (transfersomes; TFS) and conventional liposomes (CLP) were compared in their potential for transdermal delivery of meloxicam (MX). MTS, TFS and CLP were investigated for size, size distribution, zeta potential, elasticity, entrapment efficiency and stability. In vitro skin permeation using hairless mice skin was evaluated. Vesicular morphology was observed under freeze-fractured transmission electron microscopy (FF-TEM). Intrinsic thermal properties were performed using differential scanning calorimetry (DSC) and X-ray diffraction. The skin permeation mechanism was characterized using confocal laser scanning microscopy (CLSM). The results indicated that the difference in physicochemical characteristics of MTS, TFS and CLP affected the skin permeability. MTS and TFS showed higher flux of MX than CLP. CLSM image showed deformable vesicles mechanism for delivery of MX across the hairless mice skin. Our study suggested that ultradeformable and deformable liposomes (MTS and TFS) had a potential to use as transdermal drug delivery carriers for MX.
Author	Kato, Satoru Opanasopit, Praneet Obata, Yasuko Sano, Hiromu Miyoshi, Tsubasa Onuki, Yoshinori Ngawhirunpat, Tanasait Takayama, Kozo Duangjit, Sureewan
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SubjectTerms	Administration, Cutaneous Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Drug Carriers - chemistry liposome Liposomes Male Meloxicam menthol menthosome Mice Mice, Hairless Permeability Skin - metabolism Skin Absorption skin permeation Thiazines - administration & dosage Thiazines - pharmacokinetics Thiazoles - administration & dosage Thiazoles - pharmacokinetics transfersome
Title	Comparative Study of Novel Ultradeformable Liposomes: Menthosomes, Transfersomes and Liposomes for Enhancing Skin Permeation of Meloxicam
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