sb203580 preconditioning recharges matrix-expanded human adult stem cells for chondrogenesis in an inflammatory environment – A feasible approach for autologous stem cell based osteoarthritic cartilage repair

Abstract Autologous stem cells are a promising cell source for cartilage regeneration; however, cell replicative senescence and joint posttraumatic inflammation provide challenges in bringing this treatment modality to fruition. In this study, we hypothesized that preconditioning with p38 MAPK inhib...

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Bibliographic Details
Published in:	Biomaterials Vol. 64; pp. 88 - 97
Main Authors:	Zhang, Ying, Pizzute, Tyler, Li, Jingting, He, Fan, Pei, Ming
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-09-2015
Subjects:	Adult Adult Stem Cells - drug effects Advanced Basic Science Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biomedical materials Cartilage Cartilage - pathology Cartilage - physiology Cells, Cultured Chondrogenesis - drug effects Chondrogenic potential Culture Media - pharmacology Decellularized extracellular matrix Dentistry Drug Evaluation, Preclinical Extracellular Matrix Female HLA-DR Antigens - analysis Humans Imidazoles - pharmacology In Vitro Techniques Inflammation Inhibitors Interleukin-1 beta Interleukin-1beta - pharmacology Male Mesenchymal stem cell Osteoarthritis - drug therapy p38 MAPK inhibitor p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Patients Preconditioning Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Regeneration Regeneration - drug effects Rejuvenation Stem cells Surgical implants Synovial Membrane - cytology Transplantation, Autologous Mesenchymal stem cell Decellularized extracellular matrix Chondrogenic potential Preconditioning p38 MAPK inhibitor Interleukin-1 beta
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