Macrophage polarization in response to ECM coated polypropylene mesh

Abstract The host response to implanted biomaterials is a highly regulated process that influences device functionality and clinical outcome. Non-degradable biomaterials, such as knitted polypropylene mesh, frequently elicit a chronic foreign body reaction with resultant fibrosis. Previous studies h...

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Bibliographic Details
Published in:	Biomaterials Vol. 35; no. 25; pp. 6838 - 6849
Main Authors:	Wolf, Matthew T, Dearth, Christopher L, Ranallo, Christian A, LoPresti, Samuel T, Carey, Lisa E, Daly, Kerry A, Brown, Bryan N, Badylak, Stephen F
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-08-2014
Subjects:	Advanced Basic Science Animals Biomaterials Biomedical materials Coated Materials, Biocompatible - chemistry Coating Dentistry ECM (extracellular matrix) Electrochemical machining Extracellular Matrix - chemistry Female Fibrosis - pathology Foreign bodies Foreign-Body Reaction Hydrogel Hydrogels - chemistry Immunity, Innate - drug effects Macrophage Macrophages Macrophages - chemistry Materials Testing Polypropylene Polypropylenes Polypropylenes - chemistry Prostheses and Implants Rats Rats, Sprague-Dawley Surgical implants Surgical Mesh Ventral hernia ECM (extracellular matrix) Surgical mesh Hydrogel Polypropylene Ventral hernia Macrophage
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