Dietary fat and the risk of age-related maculopathy: the POLANUT Study

• Published in: European journal of clinical nutrition Vol. 61; no. 11; pp. 1341 - 1344
• Main Authors: Delcourt, C, Carrière, I, Cristol, J.P, Lacroux, A, Gerber, M
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 01-11-2007; Nature Publishing Group
• Subjects: Abnormalities; Age; Age related diseases; age-related macular degeneration; age-related maculopathy; Atrophy; Biological and medical sciences; Confidence Intervals; dietary fat; Dietary Fats - administration & dosage; Dietary Fats - adverse effects; Dietary Fats, Unsaturated - administration & dosage; Dietary Fats, Unsaturated - adverse effects; disease incidence; disease prevalence; elderly; epidemiological studies; Epidemiology; Eye diseases; fat intake; Fatty acids; fatty fish; Female; Fish; fish oils; food frequency questionnaires; food intake; France - epidemiology; Health risk assessment; Humans; Incidence; Macular degeneration; Macular Degeneration - epidemiology; Macular Degeneration - etiology; Male; mathematical models; Medical sciences; Metabolic diseases; Middle Aged; monounsaturated fatty acids; Multivariate Analysis; Nutrition; Odds Ratio; Oils & fats; Ophthalmology; Polanut study; Polyunsaturated fatty acids; Population studies; retina; Retinopathies; Risk; Risk Factors; saturated fatty acids; Surveys and Questionnaires; France; Europe; Human; age-related maculopathy; Retinopathy; Nutrition; Lipids; unsaturated fats; Epidemiology; Feeding; Eye disease; Food intake; dietary fat; Risk factor; Unsaturated fat; Age related macular degeneration; Public health
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/sj.ejcn.1602685

This study aimed at assessing the associations of dietary fat with the risk of age-related maculopathy (ARM), in the framework of a population-based study from southern France. Nutritional data were collected using a dietitian-administered food-frequency questionnaire. ARM was classified from retinal photographs using the international classification and included neovascular age-related macular degeneration, geographic atrophy, soft indistinct drusen, soft distinct drusen associated with pigmentary abnormalities. After multivariate adjustment, high total, saturated and monounsaturated fat intake were associated with increased risk for ARM (odds ratio (OR)=4.74, P=0.007; OR=2.70, P=0.04; and OR= 3.50, P=0.03, respectively). Total polyunsaturated fatty acid was not significantly associated with ARM. Total and white fish intake was not significantly associated with ARM, but fatty fish intake (more than once a month versus less than once a month) was associated with a 60% reduction in risk for ARM (OR=0.42, P=0.01).