Human NK cells confer protection against HIV-1 infection in humanized mice

The role of NK cells against HIV-1 infections remains to be elucidated in vivo. While humanized mouse models potentially could be used to directly evaluate human NK cell responses during HIV-1 infection, improved functional development of human NK cells in these hosts is needed. Here, we report the...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 132; no. 24; pp. 1 - 11
Main Authors:	Sungur, Can M, Wang, Qiankun, Ozantürk, Ayşe N, Gao, Hongbo, Schmitz, Aaron J, Cella, Marina, Yokoyama, Wayne M, Shan, Liang
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 15-12-2022
Subjects:	Animal models Animals Antibodies Antibody-Dependent Cell Cytotoxicity Antiretroviral therapy Antiviral agents Biomedical research Care and treatment Cytokines Cytotoxicity Degranulation Development and progression Drug therapy Health aspects HIV HIV infection HIV Infections HIV-1 Host-virus relationships Human immunodeficiency virus Humans Immune response Immunology Infections Inflammation Killer cells Killer Cells, Natural Ligands Lymphocytes Mice Monoclonal antibodies Natural killer cells Observations Viral Load United States NK cells Immunology
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