Spectrum of histopathological findings in coronavirus disease-19, Middle East respiratory syndrome and severe acute respiratory syndrome

• Published in: Annals of thoracic medicine Vol. 15; no. 2; pp. 52 - 53
• Main Authors: Alsaad, Khaled, Arabi, Yaseen, Hajeer, Ali
• Format: Journal Article
• Language: English
• Published: Mumbai Wolters Kluwer India Pvt. Ltd 01-04-2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Adult respiratory distress syndrome; Coronavirus infections; Coronaviruses; COVID-19; Diseases; Health aspects; Infection; Kidneys; Liver; Liver diseases; Lymphocytopenia; Medical research; Middle East respiratory syndrome; Respiratory diseases; Respiratory distress syndrome; Respiratory system agents; Shock; Viral infections; Virus diseases; China; Middle East
• ISSN: 1817-1737; 1998-3557
• DOI: 10.4103/atm.ATM_105_20

Patients with severe COVID-19 develop acute respiratory distress syndrome, acute kidney injury, cardiac dysfunction and arrhythmia, shock, gastrointestinal symptoms, lymphocytopenia, and liver dysfunction. Acute renal failure and kidney injury are commonly encountered in patients with SARS-CoV and MERS-CoV infections, and electron microscopy examination demonstrated viral particles in the renal tubular epithelial cells in SARS patients[5] and in our patient with MERS. [...]histopathological data are required on SARS-CoV-2 to better characterize the involvement of organs that are affected clinically and that has high expression of angiotensin-converting enzyme 2, including kidney, gastrointestinal tract capillaries, lymph nodes, spleen, and muscles.