UK-3A, a novel antifungal antibiotic from Streptomyces sp. 517-02: fermentation, isolation, structural elucidation and biological properties

• Published in: Journal of antibiotics Vol. 50; no. 7; p. 551
• Main Authors: Ueki, M, Kusumoto, A, Hanafi, M, Shibata, K, Tanaka, T, Taniguchi, M
• Format: Journal Article
• Language: English
• Published: Japan 1997
• Subjects: Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - pharmacology; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Chromatography, High Pressure Liquid; Fermentation; Humans; In Vitro Techniques; Lactones - chemistry; Lactones - isolation & purification; Lactones - pharmacology; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Pyridines - chemistry; Pyridines - isolation & purification; Pyridines - pharmacology; Streptomyces - classification; Streptomyces - metabolism; Tumor Cells, Cultured - drug effects
• ISSN: 0021-8820
• DOI: 10.7164/antibiotics.50.551

A novel antifungal antibiotic, UK-3A, was obtained from the mycelial cake of Streptomyces sp. 517-02. UK-3A was very similar in structure to UK-2A, a structural relative of antimycin A. The antifungal spectrum of UK-3A was relatively broad (MICs for yeasts and filamentous fungi: 1.56-6.25 and 0.39-1.56 micrograms/ml, respectively). The cytotoxic activity of UK-3A was weak (IC50: 18-100 micrograms/ml).