LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

LIS1 was first identified as a gene mutated in human classical lissencephaly sequence. LIS1 is required for dynein activity, but the underlying mechanism is poorly understood. Here, we demonstrate that LIS1 suppresses the motility of cytoplasmic dynein on microtubules (MTs), whereas NDEL1 releases t...

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Bibliographic Details
Published in:	The EMBO journal Vol. 27; no. 19; pp. 2471 - 2483
Main Authors:	Yamada, Masami, Toba, Shiori, Yoshida, Yuko, Haratani, Koji, Mori, Daisuke, Yano, Yoshihisa, Mimori-Kiyosue, Yuko, Nakamura, Takeshi, Itoh, Kyoko, Fushiki, Shinji, Setou, Mitsutoshi, Wynshaw-Boris, Anthony, Torisawa, Takayuki, Toyoshima, Yoko Y, Hirotsune, Shinji
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 08-10-2008 Nature Publishing Group UK Blackwell Publishing Ltd Nature Publishing Group
Subjects:	1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism Animals Biological Transport - physiology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Cellular biology Cytoplasm - metabolism dynein Dyneins - genetics Dyneins - metabolism Fluorescence Recovery After Photobleaching Genetics Humans LIS1 lissencephaly Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules - metabolism Molecular biology Mutation Neurons - cytology Neurons - physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Swine Tubulin - genetics Tubulin - metabolism dynein LIS1 lissencephaly
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