Intracranial compliance in type 2 diabetes mellitus and its relationship with the cardiovascular autonomic nervous control

• Published in: Brazilian journal of medical and biological research Vol. 55; no. 1; pp. 1 - e12150
• Main Authors: Galdino, G.A.M, Moura-Tonello, S.C.G, Linares, S.N, Milan-Mattos, J.C, Spavieri, D.L., Jr, Oliveira, S.M, Porta, A, Beltrame, T, Catai, A.M
• Format: Journal Article
• Language: English
• Published: Ribeirao Preto Associacao Brasileira de Divulgacao Cientifica (ABDC) 01-01-2022; Revista Brasileira de Pesquisas Medicas; Associação Brasileira de Divulgação Científica
• Subjects: Active postural change; Autonomic nervous system; Autonomic neuropathies; Baroreceptors; BIOLOGY; Blood pressure; Cardiovascular diseases; Cardiovascular modulation; Cardiovascular system; Cerebrovascular circulation; Compliance; Complications and side effects; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetic neuropathy; Diagnosis; EKG; Electrocardiogram; Electrocardiography; Health aspects; Intracranial pressure; Measurement; MEDICINE, RESEARCH & EXPERIMENTAL; Metabolic disease; Oscillations; Reflexes; Risk factors; Scalp; Type 2 diabetes; Brazil; Cerebrovascular circulation; Metabolic disease; Active postural change; Cardiovascular modulation
• ISSN: 0100-879X; 1414-431X; 1414-431X; 1678-4510
• DOI: 10.1590/1414-431X2022e12150

The intracranial compliance in type 2 diabetes mellitus (T2DM) patients and the association with cardiovascular autonomic control have not been fully elucidated. The aim of this study was to assess intracranial compliance using the noninvasive intracranial pressure (niICP) and the monitoring of waveform peaks (P1, P2, and P3) and the relationship with cardiovascular autonomic control in T2DM patients. Thirty-two men aged 40-60 years without cardiovascular autonomic neuropathy (CAN) were studied: T2DMG (n=16) and control group CG (n=16). The niICP was evaluated by a noninvasive extracranial sensor placed on the scalp. Cardiovascular autonomic control was evaluated by indices of the baroreflex sensitivity (BRS), from temporal series of R-R intervals of electrocardiogram and systolic arterial pressure, during supine and orthostatic positions. The participants remained in the supine position for 15 min and then 15 min more in orthostatism. T2DMG presented a decrease of the P2/P1 ratio during the orthostatic position (P<0.001). There was a negative moderate correlation between the P2 peak with cardiovascular coupling ([K.sup.2.sub.HP-SAP]LF) in supine (r=-0.612, P=0.011) and orthostatic (r=-0.568, P=0.020) positions in T2DMG. We concluded that T2DM patients without CAN and cardiovascular complications presented intracranial compliance similar to healthy subjects. Despite preserved intracranial adjustments, T2DM patients had a response of greater magnitude in orthostatism. In addition, the decoupling between the heart period and blood pressure signal oscillations in low frequency appeared to be related to the worsening of intracranial compliance due to the increased P2 peak. Key words: Cardiovascular modulation; Active postural change; Cerebrovascular circulation; Metabolic disease