Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)

• Published in: Journal of Veterinary Medical Science Vol. 83; no. 1; pp. 28 - 30
• Main Authors: KANO, Rui, TSUNOI, Meika, NAKAYA, Yumiko, NAGAMINE, Takashi, ONO, Koji
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01-01-2021; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Amphotericin B; antifungal susceptibility tests; Aspergillus flavus; avian aspergillosis; Fluconazole; Hyphae; Internal Medicine; Itraconazole; low-susceptibility; Micafungin; Necropsy; Okinawa rail; Voriconazole; Okinawa; avian aspergillosis; Aspergillus flavus; Okinawa rail; antifungal susceptibility tests; low-susceptibility
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.20-0380

A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revealed multifocal pyogranulomatous necrotic nodular lesions with numerous whitish-green fungal hyphae in the left air sac. Aspergillus flavus was isolated from the left air sac lesion. Antifungal susceptibility tests indicated that the isolate showed low susceptibility to amphotericin B (AMB), fluconazole (FLZ), VRZ and MCF.