Continuous Low-Level Glial Cell Line-Derived Neurotrophic Factor Delivery Using Recombinant Adeno-Associated Viral Vectors Provides Neuroprotection and Induces Behavioral Recovery in a Primate Model of Parkinson's Disease

The therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) for Parkinson's disease is likely to depend on sustained delivery of the appropriate amount to the target areas. Recombinant adeno-associated viral vectors (rAAVs) expressing GDNF may be a suitable delivery system f...

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Bibliographic Details
Published in:	The Journal of neuroscience Vol. 25; no. 4; pp. 769 - 777
Main Authors:	Eslamboli, Andisheh, Georgievska, Biljana, Ridley, Rosalind M, Baker, Harry F, Muzyczka, Nicholas, Burger, Corinna, Mandel, Ronald J, Annett, Lucy, Kirik, Deniz
Format:	Journal Article
Language:	English
Published:	United States Soc Neuroscience 26-01-2005 Society for Neuroscience
Subjects:	6-hydroxydopamine Adeno-associated virus Animals Appetitive Behavior - physiology Basic Medicine Callithrix Choice Behavior - physiology Dependovirus Disease Models, Animal dopamine Dopamine - metabolism Female GDNF gene therapy Genetic Therapy Genetic Vectors Glial Cell Line-Derived Neurotrophic Factor Green Fluorescent Proteins - biosynthesis Male Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper monkey Motor Activity - physiology Neostriatum - metabolism Neostriatum - pathology Nerve Growth Factors - administration & dosage Nerve Growth Factors - biosynthesis Nerve Growth Factors - genetics Nerve Regeneration - physiology Neurobiology of Disease Neurosciences Neurovetenskaper Oxidopamine Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson Disease, Secondary Perceptual Disorders - physiopathology Primates Recombinant Fusion Proteins - biosynthesis Substantia Nigra - metabolism Substantia Nigra - pathology Tyrosine 3-Monooxygenase - metabolism
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