The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

Intracellular transport via microtubule-based dynein and kinesin family motors plays a key role in viral reproduction and transmission. We show here that Kinesin Family Member 4 (KIF4) plays an important role in HBV/HDV infection. We intended to explore host factors impacting the HBV life cycle that...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 18; no. 3; p. e1009983
Main Authors:	Gad, Sameh A, Sugiyama, Masaya, Tsuge, Masataka, Wakae, Kosho, Fukano, Kento, Oshima, Mizuki, Sureau, Camille, Watanabe, Noriyuki, Kato, Takanobu, Murayama, Asako, Li, Yingfang, Shoji, Ikuo, Shimotohno, Kunitada, Chayama, Kazuaki, Muramatsu, Masamichi, Wakita, Takaji, Nozaki, Tomoyoshi, Aly, Hussein H
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-03-2022 Public Library of Science (PLoS)
Subjects:	Adenosine triphosphatase Agonists Biology and life sciences Care and treatment Cell division Cell surface Depletion Development and progression Dynein Family Filaments Fractionation Gene expression Genes Genetic aspects Genomes Health aspects Hep G2 Cells Hepatitis B Hepatitis B virus - physiology Hepatitis Delta Virus - physiology Humans Immunofluorescence Immunoprecipitation Infections Intracellular Kinesin Kinesins - genetics Life cycles Liver cancer Localization Medicine and Health Sciences Methods Molecular targeted therapy Organic Anion Transporters, Sodium-Dependent - genetics Organic Anion Transporters, Sodium-Dependent - metabolism Patient outcomes Proteins Receptors Research and Analysis Methods Retinoid X receptors Retinoid X Receptors - agonists siRNA Symporters - genetics Symporters - metabolism Transfection Virus Internalization Viruses Japan
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