Polygenic risk scores: from research tools to clinical instruments

Genome-wide association studies have shown unequivocally that common complex disorders have a polygenic genetic architecture and have enabled researchers to identify genetic variants associated with diseases. These variants can be combined into a polygenic risk score that captures part of an individ...

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Bibliographic Details
Published in:	Genome medicine Vol. 12; no. 1; p. 44
Main Authors:	Lewis, Cathryn M, Vassos, Evangelos
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 18-05-2020 BioMed Central BMC
Subjects:	Biotechnology industries Common disorders Direct-To-Consumer Screening and Testing Disease susceptibility Genealogy Genetic aspects Genetic diversity Genetic Predisposition to Disease Genetic Variation Genetics Genome-wide association studies Genomes Genomics Humans Initiatives Minority & ethnic groups Multifactorial Inheritance Pharmacogenetics Polygenic risk scores Population Prediction Research Design Review Risk Risk assessment Risk Factors Studies Type 2 diabetes United States Polygenic risk scores Genetics Risk Pharmacogenetics Common disorders Prediction
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