Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

Human pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune checkpoint inhibitor (ICPi). While the mechanism is not completely clear, it has been recognized that tumor microenvironment (TME) plays key roles. We investigated if targeting CD47 with a monoclonal antibody could enhance the r...

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Bibliographic Details
Published in:	Journal of hematology and oncology Vol. 12; no. 1; p. 124
Main Authors:	Pan, Yu, Lu, Fengchun, Fei, Qinglin, Yu, Xingxing, Xiong, Ping, Yu, Xunbin, Dang, Yuan, Hou, Zelin, Lin, Wenji, Lin, Xianchao, Zhang, Zheyang, Pan, Minggui, Huang, Heguang
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 27-11-2019 BioMed Central BMC
Subjects:	Adenocarcinoma Age Analysis Animal models Antibodies Antitumor activity Blood CD163 antigen CD45 antigen CD47 CD8 antigen Cell culture Cloning Committees Cytokines Genes Genomics Hematology Hospitals Immune checkpoint inhibitor Immune checkpoint inhibitors Immunohistochemistry Immunotherapy Inflammation Laboratory animals Lymphocytes Lymphocytes T Macrophages Monoclonal antibodies Oncology Pancreatic cancer Patients PD-1 protein PD-L1 PD-L1 protein Proteins Ribonucleic acid RNA RNA sequencing T cells Tumor-infiltrating lymphocytes Tumors Xenografts China Beijing China PD-L1 CD47 Immune checkpoint inhibitor Immunotherapy Pancreatic cancer
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