Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes

TAR DNA-binding protein 43 (TDP-43) is associated with a spectrum of neurodegenerative diseases. Although TDP-43 resembles heterogeneous nuclear ribonucleoproteins, its RNA targets and physiological protein partners remain unknown. Here we identify RNA targets of TDP-43 from cortical neurons by RNA...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 286; no. 2; pp. 1204 - 1215
Main Authors:	Sephton, Chantelle F., Cenik, Can, Kucukural, Alper, Dammer, Eric B., Cenik, Basar, Han, YuHong, Dewey, Colleen M., Roth, Frederick P., Herz, Joachim, Peng, Junmin, Moore, Melissa J., Yu, Gang
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 14-01-2011 American Society for Biochemistry and Molecular Biology
Subjects:	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) Animals Cerebral Cortex - cytology DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Frontotemporal Dementia FUS/TLS Gene Library Genomics HeLa Cells Humans MECP2 Mice Molecular Weight Neurobiology Neurodegeneration Neurons - cytology Neurons - physiology Proteomics PTBP2 Rats Ribonuclear Protein (RNP) RNA Metabolism RNA Stability - physiology RNA, Messenger - metabolism RNA-binding Protein RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism TDP-43 TDP-43 Proteinopathies - metabolism MECP2 Frontotemporal Dementia Neurodegeneration TDP-43 Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) FUS/TLS RNA Metabolism Ribonuclear Protein (RNP) RNA-binding Protein PTBP2
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