A rapid and sensitive liquid chromatography-tandem mass spectrometric assay for duloxetine in human plasma： Its pharmacokinetic application

This paper describes a simple, rapid and sensitive liquid chromatography tandem mass spectrometry assay for the determination of duloxetine in human plasma. A duloxetine stable labeled isotope （duloxetine ds） was used as an internal standard. Analyte and the internal standard were extracted from 100...

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Bibliographic Details
Published in:	Journal of pharmaceutical analysis Vol. 3; no. 1; pp. 36 - 44
Main Authors:	Gajula, Ramakrishna, Maddela, Rambabu, Babu Ravi, Vasu, Inamadugu, Jaswanth Kumar, Pilli, Nageswara Rao
Format:	Journal Article
Language:	English
Published:	China Elsevier B.V 01-02-2013 Wellquest Clinical Research Laboratories, Ramanthapur, Hyderabad 500013, India Xi'an Jiaotong University
Subjects:	Duloxetine in human plasma Liquid chromatography–tandem mass spectrometry Method validation Pharmacokinetic studies Solid-phase extraction (SPE) 串联质谱法人血浆力学应用固相萃取技术度洛西汀测定液相色谱灵敏 Duloxetine in human plasma Solid-phase extraction (SPE) Method validation Liquid chromatography–tandem mass spectrometry Pharmacokinetic studies Liquid chromatographytandem mass spectrometry
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