OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model

Background Glioblastoma is a malignant World Health Organization (WHO) grade IV glioma with a poor prognosis in humans. New therapeutics are desperately required. The nitrone OKN‐007 (2,4‐disulfophenyl‐PBN) has demonstrated effective anti‐glioma properties in several rodent models and is currently b...

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Bibliographic Details
Published in:	Journal of magnetic resonance imaging Vol. 42; no. 6; pp. 1582 - 1591
Main Authors:	de Souza, Patricia Coutinho, Balasubramanian, Krithika, Njoku, Charity, Smith, Natalyia, Gillespie, David L., Schwager, Andrea, Abdullah, Osama, Ritchey, Jerry W., Fung, Kar-Ming, Saunders, Debra, Jensen, Randy L., Towner, Rheal A.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-12-2015 Wiley Subscription Services, Inc
Subjects:	Administration, Oral Animals Antineoplastic Agents - administration & dosage Apoptosis Apoptosis - drug effects Benzenesulfonates - administration & dosage Brain Neoplasms - drug therapy Brain Neoplasms - pathology Cell growth Cell Line, Tumor Cell Proliferation - drug effects diffusion-weighted imaging Gangrene glioma Glioma - drug therapy Glioma - pathology Humans Imines - administration & dosage Magnetic resonance imaging Magnetic Resonance Imaging - methods necrosis Necrosis - pathology Necrosis - prevention & control NMR Nuclear magnetic resonance OKN-007 proton magnetic resonance spectroscopy Rats Rats, Inbred F344 Tumors glioma OKN-007 diffusion-weighted imaging necrosis proton magnetic resonance spectroscopy
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