Combined effects of dietary conjugated linoleic acid and sesamin on triacylglycerol and ketone body production in rat liver

• Published in: Journal of Nutritional Science and Vitaminology Vol. 48; no. 5; pp. 405 - 409
• Main Authors: Sakano, M. (Miyazaki Univ. (Japan). Faculty of Agriculture), Yuji, K, Miyanaga, F, Tamaru, S, Fujita, M, Fukuda, N, Tsutsumi, K, Iwata, T, Kasai, M, Sugano, M
• Format: Journal Article
• Language: English
• Published: Tokyo Center for Academic Publications Japan 01-10-2002
• Subjects: Animals; Anticholesteremic Agents - pharmacology; Biological and medical sciences; Body Composition - drug effects; conjugated linoleic acid; Diet; Dioxoles - pharmacology; Fundamental and applied biological sciences. Psychology; Ketone Bodies - biosynthesis; ketone body; KETONES; Lignans - pharmacology; LINOLEIC ACID; Linoleic Acid - pharmacology; Lipid Metabolism; LIVER; Liver - drug effects; Liver - metabolism; Liver. Bile. Biliary tracts; Male; Perfusion; RATS; Rats, Sprague-Dawley; sesamin; Time Factors; triacylglycerol; TRIGLYCERIDES; Triglycerides - biosynthesis; Vertebrates: digestive system; Weight Gain - drug effects; Ketone body; Rat; Digestive system; Liver; Rodentia; Lipids; Biosynthesis; Supplemented diet; Fatty acids; Feeding; Linoleic acid; Vertebrata; conjugated linoleic acid; Mammalia; Triacylglycerol; Animal; Lignan; sesamin; Conjugated compound; Macronutrient; Sesame
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.48.405

The effects of a combination of dietary conjugated Linoleic acid (CLA) supplemented with Sesamin on hepatic ketogenesis and triacylglycerol secretion were compared using the livers of rats fed diets containing 1% CLA or linoleic acid (LA) in combination with 0.2% sesamin for 14 d, respectively. The feeding of CLA, as compared to LA, caused a significant reduction in the weight of perirenal adipose tissue but not that of epididymal adipose tissue, and affected neither growth parameters nor hepatic lipid concentration. Hepatic production of ketone bodies was consistently higher in rats fed CLA than in those fed LA, while triacylglycerol secretion was reversed. No significant difference was noted in the hepatic secretion of cholesterol among the groups. Although there was no effect of the dietary combination of CLA with sesamin on adipose tissue weight, hepatic lipid parameters and ketone body production were observed: i.e., triacylglycerol secretion tended to be reduced. These results suggest that the dietary combination of CLA with sesamin may be an effective approach for lowering serum triacylglycerol levels. The decreased hepatic secretion of triacylglycerol is, in part, due to enhanced fatty acid oxidation in the liver.