Clinico‐pathological characteristics of p63 expression in B‐cell lymphoma
A member of the family of p53‐related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and clinical meaning of p63 in B‐cell lymphoma has not been elucidated. We investigated the expression pattern of p63 in B‐cell malignancies, and ev...
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| Published in: | Cancer science Vol. 97; no. 10; pp. 1050 - 1055 |
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| Abstract | A member of the family of p53‐related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and clinical meaning of p63 in B‐cell lymphoma has not been elucidated. We investigated the expression pattern of p63 in B‐cell malignancies, and evaluated the correlation between the expression of p63 and other germinal center markers. Ninety‐eight B‐cell lymphomas (28 FCL, 5 MCL, and 65 DLBCL) were analyzed by immunohistochemical examination for p63, bcl‐6, CD10 and MUM‐1 proteins, and for rearrangement of bcl‐2/IgH. Expression of p63 was observed in the nuclei of tumor cells obtained from 15 of 28 (54%) FCL, 22 of 65 (34%) DLBCL, but none of 5 MCL. In DLBCL, the expression of p63 and bcl‐6 showed a significant correlation (P < 0.02), but no correlation was observed between p63 and expression of CD10, MUM‐1, or bcl‐2/IgH rearrangement. RT‐PCR revealed that TAp63α‐type transcripts, a possible negative regulator of transcriptional activation of p21 promoter, were major transcripts in B‐cell lymphoma tissues. As for prognostic significance, only patients in the p63 positive group of FCL died, and in the non‐germinal center group, the p63 positive cases appeared to have inferior overall survival than other groups in DLBCL. Our preliminary results suggested that p63 expression is a disadvantageous factor for prognosis in this subgroup of B‐cell lymphomas. (Cancer Sci 2006; 97: 1050–1055) |
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| AbstractList | A member of the family of p53-related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and clinical meaning of p63 in B-cell lymphoma has not been elucidated. We investigated the expression pattern of p63 in B-cell malignancies, and evaluated the correlation between the expression of p63 and other germinal center markers. Ninety-eight B-cell lymphomas (28 FCL, 5 MCL, and 65 DLBCL) were analyzed by immunohistochemical examination for p63, bcl-6, CD10 and MUM-1 proteins, and for rearrangement of bcl-2/IgH. Expression of p63 was observed in the nuclei of tumor cells obtained from 15 of 28 (54%) FCL, 22 of 65 (34%) DLBCL, but none of 5 MCL. In DLBCL, the expression of p63 and bcl-6 showed a significant correlation (P < 0.02), but no correlation was observed between p63 and expression of CD10, MUM-1, or bcl-2/IgH rearrangement. RT-PCR revealed that TAp63alpha-type transcripts, a possible negative regulator of transcriptional activation of p21 promoter, were major transcripts in B-cell lymphoma tissues. As for prognostic significance, only patients in the p63 positive group of FCL died, and in the non-germinal center group, the p63 positive cases appeared to have inferior overall survival than other groups in DLBCL. Our preliminary results suggested that p63 expression is a disadvantageous factor for prognosis in this subgroup of B-cell lymphomas. A member of the family of p53 ‐related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and clinical meaning of p63 in B‐cell lymphoma has not been elucidated. We investigated the expression pattern of p63 in B‐cell malignancies, and evaluated the correlation between the expression of p63 and other germinal center markers. Ninety‐eight B‐cell lymphomas (28 FCL, 5 MCL, and 65 DLBCL) were analyzed by immunohistochemical examination for p63, bcl‐6, CD10 and MUM‐1 proteins, and for rearrangement of bcl‐2/IgH. Expression of p63 was observed in the nuclei of tumor cells obtained from 15 of 28 (54%) FCL, 22 of 65 (34%) DLBCL, but none of 5 MCL. In DLBCL, the expression of p63 and bcl‐6 showed a significant correlation ( P < 0.02), but no correlation was observed between p63 and expression of CD10, MUM‐1, or bcl‐2/IgH rearrangement. RT‐PCR revealed that TAp63α‐type transcripts, a possible negative regulator of transcriptional activation of p21 promoter, were major transcripts in B‐cell lymphoma tissues. As for prognostic significance, only patients in the p63 positive group of FCL died, and in the non‐germinal center group, the p63 positive cases appeared to have inferior overall survival than other groups in DLBCL. Our preliminary results suggested that p63 expression is a disadvantageous factor for prognosis in this subgroup of B‐cell lymphomas. ( Cancer Sci 2006; 97: 1050–1055) A member of the family of p53-related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and clinical meaning of p63 in B-cell lymphoma has not been elucidated. We investigated the expression pattern of p63 in B-cell malignancies, and evaluated the correlation between the expression of p63 and other germinal center markers. Ninety-eight B-cell lymphomas (28 FCL, 5 MCL, and 65 DLBCL) were analyzed by immunohistochemical examination for p63, bcl-6, CD10 and MUM-1 proteins, and for rearrangement of bcl-2/IgH. Expression of p63 was observed in the nuclei of tumor cells obtained from 15 of 28 (54%) FCL, 22 of 65 (34%) DLBCL, but none of 5 MCL. In DLBCL, the expression of p63 and bcl-6 showed a significant correlation (P < 0.02), but no correlation was observed between p63 and expression of CD10, MUM-1, or bcl-2/IgH rearrangement. RT-PCR revealed that TAp63alpha-type transcripts, a possible negative regulator of transcriptional activation of p21 promoter, were major transcripts in B-cell lymphoma tissues. As for prognostic significance, only patients in the p63 positive group of FCL died, and in the non-germinal center group, the p63 positive cases appeared to have inferior overall survival than other groups in DLBCL. Our preliminary results suggested that p63 expression is a disadvantageous factor for prognosis in this subgroup of B-cell lymphomas.A member of the family of p53-related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and clinical meaning of p63 in B-cell lymphoma has not been elucidated. We investigated the expression pattern of p63 in B-cell malignancies, and evaluated the correlation between the expression of p63 and other germinal center markers. Ninety-eight B-cell lymphomas (28 FCL, 5 MCL, and 65 DLBCL) were analyzed by immunohistochemical examination for p63, bcl-6, CD10 and MUM-1 proteins, and for rearrangement of bcl-2/IgH. Expression of p63 was observed in the nuclei of tumor cells obtained from 15 of 28 (54%) FCL, 22 of 65 (34%) DLBCL, but none of 5 MCL. In DLBCL, the expression of p63 and bcl-6 showed a significant correlation (P < 0.02), but no correlation was observed between p63 and expression of CD10, MUM-1, or bcl-2/IgH rearrangement. RT-PCR revealed that TAp63alpha-type transcripts, a possible negative regulator of transcriptional activation of p21 promoter, were major transcripts in B-cell lymphoma tissues. As for prognostic significance, only patients in the p63 positive group of FCL died, and in the non-germinal center group, the p63 positive cases appeared to have inferior overall survival than other groups in DLBCL. Our preliminary results suggested that p63 expression is a disadvantageous factor for prognosis in this subgroup of B-cell lymphomas. A member of the family of p53‐related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and clinical meaning of p63 in B‐cell lymphoma has not been elucidated. We investigated the expression pattern of p63 in B‐cell malignancies, and evaluated the correlation between the expression of p63 and other germinal center markers. Ninety‐eight B‐cell lymphomas (28 FCL, 5 MCL, and 65 DLBCL) were analyzed by immunohistochemical examination for p63, bcl‐6, CD10 and MUM‐1 proteins, and for rearrangement of bcl‐2/IgH. Expression of p63 was observed in the nuclei of tumor cells obtained from 15 of 28 (54%) FCL, 22 of 65 (34%) DLBCL, but none of 5 MCL. In DLBCL, the expression of p63 and bcl‐6 showed a significant correlation (P < 0.02), but no correlation was observed between p63 and expression of CD10, MUM‐1, or bcl‐2/IgH rearrangement. RT‐PCR revealed that TAp63α‐type transcripts, a possible negative regulator of transcriptional activation of p21 promoter, were major transcripts in B‐cell lymphoma tissues. As for prognostic significance, only patients in the p63 positive group of FCL died, and in the non‐germinal center group, the p63 positive cases appeared to have inferior overall survival than other groups in DLBCL. Our preliminary results suggested that p63 expression is a disadvantageous factor for prognosis in this subgroup of B‐cell lymphomas. (Cancer Sci 2006; 97: 1050–1055) A member of the family of p53-related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and clinical meaning of p63 in B-cell lymphoma has not been elucidated. We investigated the expression pattern of p63 in B-cell malignancies, and evaluated the correlation between the expression of p63 and other germinal center markers. Ninety-eight B-cell lymphomas (28 FCL, 5 MCL, and 65 DLBCL) were analyzed by immunohistochemical examination for p63, bcl-6, CD10 and MUM-1 proteins, and for rearrangement of bcl-2/IgH. Expression of p63 was observed in the nuclei of tumor cells obtained from 15 of 28 (54%) FCL, 22 of 65 (34%) DLBCL, but none of 5 MCL. In DLBCL, the expression of p63 and bcl-6 showed a significant correlation (P < 0.02), but no correlation was observed between p63 and expression of CD10, MUM-1, or bcl-2/IgH rearrangement. RT-PCR revealed that TAp63 alpha -type transcripts, a possible negative regulator of transcriptional activation of p21 promoter, were major transcripts in B-cell lymphoma tissues. As for prognostic significance, only patients in the p63 positive group of FCL died, and in the non-germinal center group, the p63 positive cases appeared to have inferior overall survival than other groups in DLBCL. Our preliminary results suggested that p63 expression is a disadvantageous factor for prognosis in this subgroup of B-cell lymphomas. (Cancer Sci 2006; 97: 1050-1055) |
| Author | Fukushima, Noriyasu Sueoka, Eisaburo Funai, Noriko Sano, Masayuki Sato, Akemi Satoh, Toshimi Tsuneyoshi, Naoko Ide, Masaru Hisatomi, Takashi Tokunaga, Osamu Tomimasu, Rika Sueoka, Naoko Kuwahara, Nobuo |
| AuthorAffiliation | 1 Departments of Internal Medicine 4 Department of Internal Medicine, Maeda Hospital, Imari, Saga, Japan 2 Pathology, and 3 Blood Transfusion Medicine, Faculty of Medicine, Saga University, 1 Honjo‐machi, Saga‐city, Saga, Japan; and |
| AuthorAffiliation_xml | – name: 3 Blood Transfusion Medicine, Faculty of Medicine, Saga University, 1 Honjo‐machi, Saga‐city, Saga, Japan; and – name: 1 Departments of Internal Medicine – name: 2 Pathology, and – name: 4 Department of Internal Medicine, Maeda Hospital, Imari, Saga, Japan |
| Author_xml | – sequence: 1 givenname: Noriyasu surname: Fukushima fullname: Fukushima, Noriyasu – sequence: 2 givenname: Toshimi surname: Satoh fullname: Satoh, Toshimi – sequence: 3 givenname: Naoko surname: Sueoka fullname: Sueoka, Naoko – sequence: 4 givenname: Akemi surname: Sato fullname: Sato, Akemi – sequence: 5 givenname: Masaru surname: Ide fullname: Ide, Masaru – sequence: 6 givenname: Takashi surname: Hisatomi fullname: Hisatomi, Takashi – sequence: 7 givenname: Nobuo surname: Kuwahara fullname: Kuwahara, Nobuo – sequence: 8 givenname: Rika surname: Tomimasu fullname: Tomimasu, Rika – sequence: 9 givenname: Naoko surname: Tsuneyoshi fullname: Tsuneyoshi, Naoko – sequence: 10 givenname: Noriko surname: Funai fullname: Funai, Noriko – sequence: 11 givenname: Masayuki surname: Sano fullname: Sano, Masayuki – sequence: 12 givenname: Osamu surname: Tokunaga fullname: Tokunaga, Osamu – sequence: 13 givenname: Eisaburo surname: Sueoka fullname: Sueoka, Eisaburo |
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| Keywords | Human Cancerology Prognosis Lymphoproliferative syndrome Genetics Malignant hemopathy B-Lymphocyte Gene expression Non Hodgkin lymphoma |
| Language | English |
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| Snippet | A member of the family of p53‐related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and... A member of the family of p53-related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and... A member of the family of p53 ‐related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and... |
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| SubjectTerms | Adult Aged Aged, 80 and over Alternative Splicing Biological and medical sciences DNA-Binding Proteins - analysis DNA-Binding Proteins - genetics Female Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - mortality Lymphoma, B-Cell - pathology Male Medical sciences Middle Aged Original Prognosis RNA, Messenger - analysis Trans-Activators - analysis Trans-Activators - genetics Transcription Factors Tumor Suppressor Proteins - analysis Tumor Suppressor Proteins - genetics Tumors |
| Title | Clinico‐pathological characteristics of p63 expression in B‐cell lymphoma |
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