SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200-500 μM) compared with other mammals (3-120 μM). About 70% of daily urate disposal occurs via the kidneys, and in 5-25% of...

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Bibliographic Details
Published in:	Nature genetics Vol. 40; no. 4; pp. 437 - 442
Main Authors:	Wright, Alan F, Vitart, Veronique, Rudan, Igor, Hayward, Caroline, Gray, Nicola K, Floyd, James, Palmer, Colin NA, Knott, Sara A, Kolcic, Ivana, Polasek, Ozren, Graessler, Juergen, Wilson, James F, Marinaki, Anthony, Riches, Philip L, Shu, Xinhua, Janicijevic, Branka, Smolej-Narancic, Nina, Gorgoni, Barbara, Morgan, Joanne, Campbell, Susan, Biloglav, Zrinka, Barac-Lauc, Lovorka, Pericic, Marijana, Klaric, Irena Martinovic, Zgaga, Lina, Skaric-Juric, Tatjana, Wild, Sarah H, Richardson, William A, Hohenstein, Peter, Kimber, Charley H, Tenesa, Albert, Donnelly, Louise A, Fairbanks, Lynette D, Aringer, Martin, McKeigue, Paul M, Ralston, Stuart H, Morris, Andrew D, Rudan, Pavao, Hastie, Nicholas D, Campbell, Harry
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-04-2008 Nature Publishing Group
Subjects:	Acids Adolescent Adult Aged Aged, 80 and over Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biological Transport, Active Biomarkers - blood Biomarkers - urine Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Case-Control Studies Complications and side effects Croatia Crystals Diagnosis Diseases of the osteoarticular system Excretion Female Fructose - metabolism Fundamental and applied biological sciences. Psychology Gene Function Genetic Linkage Genetic variance Genetics of eukaryotes. Biological and molecular evolution Genome, Human Genomics Genotype Germany Glucose Transport Proteins, Facilitative - physiology Gout Gout - blood Gout - urine Health aspects Human Genetics Human populations Humans Hyperuricemia Inflammatory joint diseases Kidneys letter Male Mammals Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Molecular Sequence Data Oocytes - cytology Oocytes - metabolism Organic Anion Transporters - metabolism Polymorphism, Single Nucleotide - genetics Population genetics Rheumatism Risk factors Uric acid Uric Acid - blood Urinary tract diseases Xenopus laevis Xenopus laevis - metabolism Germany Croatia British Isles Hyperuricemia Excretion Gout Diseases of the osteoarticular system Metabolic diseases Serum Purine Uric acid Concentration Microcristalline arthropathy Microcrystal
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