Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1): a phase 3, randomised, double-blind, multicentre trial

Summary Background mTOR inhibition reverses trastuzumab resistance via the hyperactivated PIK/AKT/mTOR pathway due to PTEN loss, by sensitising PTEN-deficient tumours to trastuzumab. The BOLERO-1 study assessed the efficacy and safety of adding everolimus to trastuzumab and paclitaxel as first-line...

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Published in:	The lancet oncology Vol. 16; no. 7; pp. 816 - 829
Main Authors:	Hurvitz, Sara A, Dr, Andre, Fabrice, Prof, Jiang, Zefei, Prof, Shao, Zhimin, Prof, Mano, Max S, MD, Neciosup, Silvia P, MD, Tseng, Ling-Min, MD, Zhang, Qingyuan, Prof, Shen, Kunwei, Prof, Liu, Donggeng, Prof, Dreosti, Lydia M, Prof, Burris, Howard A, MD, Toi, Masakazu, Prof, Buyse, Marc E, Prof, Cabaribere, David, MSc, Lindsay, Mary-Ann, PhD, Rao, Shantha, PhD, Pacaud, Lida Bubuteishvili, MD, Taran, Tetiana, MD, Slamon, Dennis, Prof
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-07-2015 Elsevier Limited
Subjects:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - blood Breast cancer Breast Neoplasms - blood Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer therapies Chemotherapy Clinical trials Disease-Free Survival Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Endocrine therapy Everolimus Female Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate Maximum Tolerated Dose Medical prognosis Metastasis Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging Ovarian cancer Paclitaxel - administration & dosage Paclitaxel - adverse effects Patients Proportional Hazards Models Receptor, ErbB-2 - blood Sirolimus - administration & dosage Sirolimus - adverse effects Sirolimus - analogs & derivatives Survival Analysis Trastuzumab Treatment Outcome Tumors Young Adult
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