Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation

Angiogenesis, in particular anti-angiogenesis, is an area of particular therapeutic interest in cancer treatment. Several anti-angiogenic agents are in the final stages of clinical trials. One of these agents, thalidomide, best known for its teratogenic potential, is showing promise against several...

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Bibliographic Details
Published in:	Biological & pharmaceutical bulletin Vol. 25; no. 5; pp. 597 - 604
Main Authors:	Marks, Megan G., Shi, Jiandong, Fry, Michael O., Xiao, Zili, Trzyna, Michelle, Pokala, Vedavalli, Ihnat, Michael A., Li, Pui-Kai
Format:	Journal Article
Language:	English
Published:	Tokyo The Pharmaceutical Society of Japan 01-05-2002 Maruzen Japan Science and Technology Agency
Subjects:	angiogenesis Angiogenesis Inhibitors Animals Antimetabolites - pharmacology Antineoplastic agents Biological and medical sciences Blood Vessels - drug effects Bromodeoxyuridine - pharmacology Cell Division - drug effects Chick Embryo chorioallantoic membrane (CAM) assay Chorion - blood supply cytotoxicity Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Enzyme-Linked Immunosorbent Assay General aspects Humans Hydroxylation In Vitro Techniques Medical sciences Microsomes, Liver - metabolism Pharmacology. Drug treatments Rats Regional Blood Flow thalidomide Thalidomide - metabolism Thalidomide - pharmacology Tumor Cells, Cultured Antineoplastic agent Human Cell proliferation Endothelial cell Embryo Hydroxylation Metabolite In vitro Biological activity Angiogenesis Vertebrata Chorioallantoic membrane Animal Chicken Aves Antiangiogenic agent Thalidomide Tumor cell
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