TRAIP is a master regulator of DNA interstrand crosslink repair

Cells often use multiple pathways to repair the same DNA lesion, and the choice of pathway has substantial implications for the fidelity of genome maintenance. DNA interstrand crosslinks covalently link the two strands of DNA, and thereby block replication and transcription; the cytotoxicity of thes...

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Bibliographic Details
Published in:	Nature (London) Vol. 567; no. 7747; pp. 267 - 272
Main Authors:	Wu, R. Alex, Semlow, Daniel R., Kamimae-Lanning, Ashley N., Kochenova, Olga V., Chistol, Gheorghe, Hodskinson, Michael R., Amunugama, Ravindra, Sparks, Justin L., Wang, Meng, Deng, Lin, Mimoso, Claudia A., Low, Emily, Patel, Ketan J., Walter, Johannes C.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-03-2019 Nature Publishing Group
Subjects:	101/28 13/106 42/41 631/337/1427 631/45/147 64/114 82/1 82/29 82/83 Adenosine triphosphatase Anemia Animals ATPases Cancer treatment Cdc45 protein Chains Chemotherapy Crosslinking Cytotoxicity Deoxyribonucleic acid DNA DNA - biosynthesis DNA - chemistry DNA - metabolism DNA helicase DNA Helicases - chemistry DNA Helicases - metabolism DNA Repair DNA Replication Fanconi's anemia Female Genetic regulation Genetic research Genomes Genomics Homology Humanities and Social Sciences Humans Letter Ligases Mammals Minichromosome Maintenance Complex Component 7 - metabolism multidisciplinary Mutation N-Glycosyl Hydrolases - metabolism Protein Binding Proteins Repair Replication Replication forks Resveratrol Science Science (multidisciplinary) Toxicity Transcription Transcription (Genetics) Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Ubiquitination Unloading Xenopus
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