COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an obser...

Full description

Saved in:

Bibliographic Details
Published in:	Nature (London) Vol. 468; no. 7326; pp. 968 - 972
Main Authors:	Emery, Caroline M, Hieronymus, Haley, Zhao, Jean J, Boehm, Jesse S, Golub, Todd, Yang, Xiaoping, Root, David E, Roberts, Thomas M, Hahn, William C, Hill, David E, Wilson, Christopher J, Weber, Barbara L, Garraway, Levi A, Johnson, Laura A, Kim, Sungjoon, Harris, Jennifer L, Kim, So Young, Vidal, Marc, Finan, Peter M, Myer, Vic E, Sellers, William R, Barretina, Jordi, Alkan, Ozan, Thomas, Sapana R, Wardwell, Leslie, Cogdill, Alexandria P, Dummer, Reinhard, Schlegel, Robert, Stransky, Nicolas, Flaherty, Keith T, Wargo, Jennifer A, Murray, Ryan R, Johannessen, Cory M, Salehi-Ashtiani, Kourosh, Caponigro, Giordano
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16-12-2010 Nature Publishing Group
Subjects:	631/67/1059/2326 692/699/67/1813/1634 Allosteric Regulation Antineoplastic agents Biochemistry Biological and medical sciences Cancer Cancer cells Cell Line, Tumor Cell lines Clinical Trials as Topic Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Enzyme Activation - drug effects Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Library General aspects Genes Humanities and Social Sciences Humans Indoles - pharmacology Indoles - therapeutic use Kinases letter MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism MAP Kinase Signaling System Medical sciences Melanoma Melanoma - drug therapy Melanoma - enzymology Melanoma - genetics Melanoma - metabolism Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism multidisciplinary Mutation Open Reading Frames - genetics Pharmacology. Drug treatments Properties Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein kinases Protein research Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - chemistry Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins c-raf - genetics Proto-Oncogene Proteins c-raf - metabolism Science Science (multidisciplinary) Sulfonamides - pharmacology Sulfonamides - therapeutic use Vemurafenib United States Antineoplastic agent Human Treatment resistance Enzyme Transferases Enzyme inhibitor Mitogen-activated protein kinase Malignant tumor Open reading frame Cancerology Cell line Malignant melanoma Genetics Cancer
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!