Oncogenic role of Merlin/NF2 in glioblastoma

Glioblastoma is the most common and aggressive primary brain tumor in adults, with a poor prognosis because of its resistance to radiotherapy and chemotherapy. Merlin/ NF2 (moesin-ezrin-radixin-like protein/neurofibromatosis type 2) is a tumor suppressor found to be mutated in most nervous system tu...

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Bibliographic Details
Published in:	Oncogene Vol. 34; no. 20; pp. 2621 - 2630
Main Authors:	Guerrero, P A, Yin, W, Camacho, L, Marchetti, D
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14-05-2015 Nature Publishing Group
Subjects:	13 13/106 13/109 13/31 13/44 13/95 42 42/35 42/44 59 631/80/83 64 64/60 Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors - biosynthesis Basic Helix-Loop-Helix Transcription Factors - genetics Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Cell Biology Cell Line, Tumor Cell proliferation Chemotherapy Contact inhibition Cyclin D1 Cyclin D1 - biosynthesis Cyclin D1 - genetics Drug resistance Enhancer-of-split protein Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - biosynthesis ErbB Receptors - genetics Ezrin Female Gene Expression Regulation, Neoplastic - genetics Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma cells Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Human Genetics Humans Internal Medicine Kinases Medicine Medicine & Public Health Mice Mice, Nude Moesin Mutation Nervous system Neurofibromatosis Neurofibromatosis 2 Neurofibromin 2 Neurofibromin 2 - genetics Neurofibromin 2 - metabolism Notch1 protein Oncology original-article Phosphorylation Phosphorylation - genetics Proteins Radiation therapy Radiology Radixin Receptor, Notch1 - biosynthesis Receptor, Notch1 - genetics Serine Transcription Factor HES-1 Tumor suppressor genes Tumorigenesis Tumors
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