Insights from the worm: The C. elegans model for innate immunity

Highlights • C. elegans as ancestral metazoan system for studying innate immunity. • The RNAi machinery is important for anti-viral defense. • Pathogen response to bacterial infections are mediated by MAPK signaling. • Innate immunity is linked to stress responses and longevity regulation. • Germlin...

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Bibliographic Details
Published in:	Seminars in immunology Vol. 26; no. 4; pp. 303 - 309
Main Authors:	Ermolaeva, Maria A, Schumacher, Björn
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2014
Subjects:	Allergy and Immunology Ancestral immunity Animals C. elegans Caenorhabditis elegans - cytology Caenorhabditis elegans - immunology Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - immunology Caenorhabditis elegans Proteins - metabolism Host–pathogen interaction Humans Immunity, Innate Innate immunity Models, Animal Regeneration Innate immunity Host–pathogen interaction Ancestral immunity C. elegans
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Summary:	Highlights • C. elegans as ancestral metazoan system for studying innate immunity. • The RNAi machinery is important for anti-viral defense. • Pathogen response to bacterial infections are mediated by MAPK signaling. • Innate immunity is linked to stress responses and longevity regulation. • Germline DNA damage induces systemic stress resistance (GDISR) through innate immune signaling.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1044-5323 1096-3618
DOI:	10.1016/j.smim.2014.04.005