1003-P: FINDRISC Identifies Diabetes Due to Insulin Resistance but Not ß-Cell Failure

• Published in: Diabetes (New York, N.Y.) Vol. 70; no. Supplement_1
• Main Authors: WENTZEL, ANNEMARIE, ISHIMWE, MARIE CONSOLATRICE SAGE, SHOUP, ELYSSA M., OSEI-TUTU, NANA H., PATTERSON, ARIELLE, HORMENU, THOMAS, DUBOSE, CHRISTOPHER, HORLYCK-ROMANOVSKY, MARGRETHE F., SUMNER, ANNE E.
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01-06-2021
• Subjects: Beta cells; Diabetes; Diabetes mellitus; Etiology; Insulin; Insulin resistance
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/db21-1003-P

Diabetes (DM) prediction scores such as the Finnish Diabetes Risk Score (FINDRISC) assume that insulin resistance (IR) is the cause of DM. Yet, data in Africans suggest β-cell failure rather than IR is often the cause of DM. It is unknown if FINDRISC's ability to predict DM differs when the cause is β-cell failure rather than IR. Our two goals in 181 Africans with Abnl-GT (a term for both DM and preDM) was to determine the prevalence of IR vs. β-cell failure and FINDRISC's ability to predict DM in each group. Diagnosis of AbnlGT-IR required both AbnlGT and HOMA-IR≥2.1. AbnlGT-β-cell-failure required both AbnlGT and HOMA-IR<2.1. DM was diagnosed by OGTT or A1C. FINDRISC includes age, BMI, WC, BP meds, DM family hx. Logistic regression determined odds of DM if FINDRISC≥9. In this cohort with AbnlGT, the prevalence of IR was 38% (68/181) and β-cell failure was 62% (113/181). Age did not differ by group but the IR group had higher BMI and WC. DM prevalence was higher in the IR than the β-cell failure group (32% (22/68) vs. 13% (15/113), P<0.01). In the entire cohort the odds of DM if FINDRISC≥9 was 2.4 (95%CI, 1.1, 5.2) P=0.022 (Fig). In the IR group the odds of DM if FINDRISC≥9 was 5.4 (95%CI, 2.9, 10.4) P<0.003. In the β-cell failure group the odds of DM if FINDRISC≥9 was 1.5 (95%CI, 0.9, 2.9) P=0.111. Hence, FINDRISC is highly effective in predicting DM if the etiology is IR. Scores which predict DM when the etiology is primarily β-cell failure await development.