Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance in breast cancer represent prognostic indicators for recurrence-free and overall survival. We provide evidence that response to chemotherapy...
Saved in:
| Published in: | Cancer discovery Vol. 1; no. 1; p. 54 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
01-06-2011
|
| Subjects: | |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance in breast cancer represent prognostic indicators for recurrence-free and overall survival. We provide evidence that response to chemotherapy is in part regulated by these leukocytes; cytotoxic therapies induce mammary epithelial cells to produce monocyte/macrophage recruitment factors, including colony stimulating factor 1 (CSF1) and interleukin-34, which together enhance CSF1 receptor (CSF1R)-dependent macrophage infiltration. Blockade of macrophage recruitment with CSF1R-signaling antagonists, in combination with paclitaxel, improved survival of mammary tumor-bearing mice by slowing primary tumor development and reducing pulmonary metastasis. These improved aspects of mammary carcinogenesis were accompanied by decreased vessel density and appearance of antitumor immune programs fostering tumor suppression in a CD8+ T-cell-dependent manner. These data provide a rationale for targeting macrophage recruitment/response pathways, notably CSF1R, in combination with cytotoxic therapy, and identification of a breast cancer population likely to benefit from this novel therapeutic approach.
These findings reveal that response to chemotherapy is in part regulated by the tumor immune microenvironment and that common cytotoxic drugs induce neoplastic cells to produce monocyte/macrophage recruitment factors, which in turn enhance macrophage infiltration into mammary adenocarcinomas. Blockade of pathways mediating macrophage recruitment, in combination with chemotherapy, significantly decreases primary tumor progression, reduces metastasis, and improves survival by CD8+ T-cell-dependent mechanisms, thus indicating that the immune microenvironment of tumors can be reprogrammed to instead foster antitumor immunity and improve response to cytotoxic therapy. |
|---|---|
| AbstractList | Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance in breast cancer represent prognostic indicators for recurrence-free and overall survival. We provide evidence that response to chemotherapy is in part regulated by these leukocytes; cytotoxic therapies induce mammary epithelial cells to produce monocyte/macrophage recruitment factors, including colony stimulating factor 1 (CSF1) and interleukin-34, which together enhance CSF1 receptor (CSF1R)-dependent macrophage infiltration. Blockade of macrophage recruitment with CSF1R-signaling antagonists, in combination with paclitaxel, improved survival of mammary tumor-bearing mice by slowing primary tumor development and reducing pulmonary metastasis. These improved aspects of mammary carcinogenesis were accompanied by decreased vessel density and appearance of antitumor immune programs fostering tumor suppression in a CD8+ T-cell-dependent manner. These data provide a rationale for targeting macrophage recruitment/response pathways, notably CSF1R, in combination with cytotoxic therapy, and identification of a breast cancer population likely to benefit from this novel therapeutic approach.
These findings reveal that response to chemotherapy is in part regulated by the tumor immune microenvironment and that common cytotoxic drugs induce neoplastic cells to produce monocyte/macrophage recruitment factors, which in turn enhance macrophage infiltration into mammary adenocarcinomas. Blockade of pathways mediating macrophage recruitment, in combination with chemotherapy, significantly decreases primary tumor progression, reduces metastasis, and improves survival by CD8+ T-cell-dependent mechanisms, thus indicating that the immune microenvironment of tumors can be reprogrammed to instead foster antitumor immunity and improve response to cytotoxic therapy. |
| Author | Keil, Scott D Hwang, E Shelley Rugo, Hope S DeNardo, David G Jirström, Karin Coussens, Lisa M West, Brian L Rexhepaj, Elton Gallagher, William M Madden, Stephen F Junaid, Sharfaa A Brennan, Donal J Ruffell, Brian Shiao, Stephen L Wadhwani, Nikhil |
| Author_xml | – sequence: 1 givenname: David G surname: DeNardo fullname: DeNardo, David G organization: Department of Pathology, University of California, San Francisco, USA – sequence: 2 givenname: Donal J surname: Brennan fullname: Brennan, Donal J – sequence: 3 givenname: Elton surname: Rexhepaj fullname: Rexhepaj, Elton – sequence: 4 givenname: Brian surname: Ruffell fullname: Ruffell, Brian – sequence: 5 givenname: Stephen L surname: Shiao fullname: Shiao, Stephen L – sequence: 6 givenname: Stephen F surname: Madden fullname: Madden, Stephen F – sequence: 7 givenname: William M surname: Gallagher fullname: Gallagher, William M – sequence: 8 givenname: Nikhil surname: Wadhwani fullname: Wadhwani, Nikhil – sequence: 9 givenname: Scott D surname: Keil fullname: Keil, Scott D – sequence: 10 givenname: Sharfaa A surname: Junaid fullname: Junaid, Sharfaa A – sequence: 11 givenname: Hope S surname: Rugo fullname: Rugo, Hope S – sequence: 12 givenname: E Shelley surname: Hwang fullname: Hwang, E Shelley – sequence: 13 givenname: Karin surname: Jirström fullname: Jirström, Karin – sequence: 14 givenname: Brian L surname: West fullname: West, Brian L – sequence: 15 givenname: Lisa M surname: Coussens fullname: Coussens, Lisa M |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22039576$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j9FKwzAYhYMobs69gUheoDNNmya9lKFTKHij1-Nv8tdW26Qk6bBvb8F5br7Dd3Hg3JBL6ywScpeyXZoK9cBTUSaKy3ynTZKyhDGuLsj6rEu2ItsQvtiSvMwFk9dkxTnLSiGLNWkrnL6dniNS7Yaxx58uznT0aDodA609QohUg9XoaZj8qTtBT8Ea2kxWx85Z6PuZevyceogYlhZGZwPS6KhucXCxRQ_jfEuuGugDbs_ckI_np_f9S1K9HV73j1Wii1zEBI0qc4mZ0bWBvBGMS5nWBQezuCwr64xDIQQowVFqQBAgFNZGqkIKlMA35P5vd5zqAc1x9N0Afj7-X-a_r9ReAA |
| CitedBy_id | crossref_primary_10_1073_pnas_1201091109 crossref_primary_10_1038_cdd_2013_60 crossref_primary_10_1073_pnas_1219457110 crossref_primary_10_1002_adfm_202100386 crossref_primary_10_1016_j_imbio_2013_09_003 crossref_primary_10_1021_acsptsci_3c00213 crossref_primary_10_1186_s12943_015_0409_y crossref_primary_10_1016_j_celrep_2017_03_037 crossref_primary_10_1016_j_celrep_2017_03_038 crossref_primary_10_1158_2326_6066_CIR_15_0052 crossref_primary_10_1016_j_intimp_2021_108427 crossref_primary_10_3389_fonc_2021_691246 crossref_primary_10_1016_j_yexcr_2013_04_017 crossref_primary_10_1016_j_ccell_2024_04_002 crossref_primary_10_1159_000430499 crossref_primary_10_1186_s12929_022_00881_4 crossref_primary_10_3892_ijmm_2016_2620 crossref_primary_10_1158_1535_7163_MCT_16_0866 crossref_primary_10_3390_cancers13020316 crossref_primary_10_1101_pdb_top078816 crossref_primary_10_36401_JIPO_23_16 crossref_primary_10_1007_s12038_023_00386_8 crossref_primary_10_1038_s41568_023_00567_5 crossref_primary_10_1158_1535_7163_MCT_17_0241 crossref_primary_10_1016_j_celrep_2020_107643 crossref_primary_10_15252_emmm_201607445 crossref_primary_10_1016_j_it_2011_12_001 crossref_primary_10_3389_fcell_2018_00056 crossref_primary_10_1146_annurev_cancerbio_060220_014137 crossref_primary_10_1172_JCI94586 crossref_primary_10_1016_j_canlet_2019_07_002 crossref_primary_10_1186_s12916_015_0431_3 crossref_primary_10_1038_s41392_021_00658_5 crossref_primary_10_4103_IJPM_IJPM_67_18 crossref_primary_10_1038_cdd_2013_67 crossref_primary_10_3390_biomedicines10030557 crossref_primary_10_3389_fonc_2020_00748 crossref_primary_10_1158_2326_6066_CIR_15_0036 crossref_primary_10_1371_journal_pone_0271203 crossref_primary_10_1593_neo_13706 crossref_primary_10_18632_oncotarget_25226 crossref_primary_10_1007_s00432_023_04950_5 crossref_primary_10_2139_ssrn_3985187 crossref_primary_10_1097_MD_0000000000023321 crossref_primary_10_1371_journal_pone_0097580 crossref_primary_10_1158_1541_7786_MCR_16_0387 crossref_primary_10_1158_1078_0432_CCR_20_0614 crossref_primary_10_7243_2052_6199_4_1 crossref_primary_10_1158_1078_0432_CCR_20_0855 crossref_primary_10_1016_j_bbadis_2023_166746 crossref_primary_10_1016_S0007_4551_18_30395_3 crossref_primary_10_1016_j_ccell_2016_03_005 crossref_primary_10_1172_JCI145296 crossref_primary_10_18632_oncotarget_23289 crossref_primary_10_1021_acs_jmedchem_0c00936 crossref_primary_10_1038_s41577_019_0127_6 crossref_primary_10_1007_s00018_018_2997_3 crossref_primary_10_1074_mcp_RA117_000443 crossref_primary_10_1155_2017_9624760 crossref_primary_10_3389_fonc_2020_00745 crossref_primary_10_1007_s00262_011_1079_2 crossref_primary_10_1007_s10911_014_9326_8 crossref_primary_10_1016_j_ctrv_2012_04_011 crossref_primary_10_1016_j_molmed_2018_03_006 crossref_primary_10_1371_journal_pone_0051379 crossref_primary_10_18632_oncotarget_7097 crossref_primary_10_1158_1078_0432_CCR_17_1007 crossref_primary_10_1080_2162402X_2015_1089381 crossref_primary_10_1038_s41467_018_05346_7 crossref_primary_10_1038_s41467_018_03600_6 crossref_primary_10_1016_j_celrep_2019_07_078 crossref_primary_10_1016_j_molonc_2015_10_003 crossref_primary_10_1158_0008_5472_CAN_15_3332 crossref_primary_10_1073_pnas_2017198118 crossref_primary_10_3389_fcell_2018_00038 crossref_primary_10_1016_j_immuni_2013_08_025 crossref_primary_10_3892_ijo_2015_3075 crossref_primary_10_1038_nm_4123 crossref_primary_10_1016_j_bulcan_2018_03_004 crossref_primary_10_1016_j_tcb_2014_11_006 crossref_primary_10_4161_onci_20226 crossref_primary_10_1002_ijc_28451 crossref_primary_10_1016_j_yexcr_2013_03_007 crossref_primary_10_21769_BioProtoc_4012 crossref_primary_10_1080_13543784_2017_1303045 crossref_primary_10_1016_j_biotechadv_2016_04_005 crossref_primary_10_1158_0008_5472_CAN_13_0842 crossref_primary_10_1016_j_pharmthera_2016_03_003 crossref_primary_10_1172_JCI97642 crossref_primary_10_1016_j_biomaterials_2016_06_032 crossref_primary_10_1007_s00281_013_0367_7 crossref_primary_10_1038_ncb3015 crossref_primary_10_1016_j_celrep_2023_112620 crossref_primary_10_1007_s13277_016_5349_7 crossref_primary_10_1038_onc_2012_166 crossref_primary_10_3389_fendo_2019_00547 crossref_primary_10_1016_j_intimp_2019_105864 crossref_primary_10_1016_j_ccr_2014_05_016 crossref_primary_10_1186_s13058_015_0549_4 crossref_primary_10_1016_j_ccr_2012_02_022 crossref_primary_10_1007_s00535_014_0943_1 crossref_primary_10_1007_s10456_018_9613_x crossref_primary_10_1158_1078_0432_CCR_17_2587 crossref_primary_10_1007_s00262_014_1576_1 crossref_primary_10_1016_j_trecan_2023_02_001 crossref_primary_10_1126_sciadv_abl9171 crossref_primary_10_1667_RR13493_1 crossref_primary_10_1371_journal_pone_0064225 crossref_primary_10_1016_j_celrep_2018_03_131 crossref_primary_10_1002_JLB_3MIR0320_475R crossref_primary_10_1158_1535_7163_MCT_13_0356 crossref_primary_10_1007_s00418_018_1744_z crossref_primary_10_1016_j_biomaterials_2021_120998 crossref_primary_10_1158_0008_5472_CAN_15_2663 crossref_primary_10_3389_fimmu_2017_00506 crossref_primary_10_1073_pnas_2209856120 crossref_primary_10_1172_jci_insight_155300 crossref_primary_10_1016_j_hoc_2014_03_002 crossref_primary_10_1158_1535_7163_MCT_17_0019 crossref_primary_10_18632_oncotarget_968 crossref_primary_10_1016_j_semradonc_2019_12_004 crossref_primary_10_1586_1744666X_2014_929943 crossref_primary_10_3390_cancers12030725 crossref_primary_10_1016_j_ccell_2021_07_002 crossref_primary_10_3389_fimmu_2020_01633 crossref_primary_10_1038_nri3175 crossref_primary_10_1016_j_ccr_2012_02_017 crossref_primary_10_1002_jcp_27027 crossref_primary_10_1016_j_pneurobio_2022_102306 crossref_primary_10_1021_acsnano_9b07984 crossref_primary_10_1080_15321819_2023_2285501 crossref_primary_10_1530_ERC_14_0096 crossref_primary_10_1038_nrc3498 crossref_primary_10_1371_journal_pone_0107483 crossref_primary_10_1158_2159_8290_CD_20_1808 crossref_primary_10_1186_1471_2407_14_257 crossref_primary_10_4161_onci_24614 crossref_primary_10_1200_EDBK_158948 crossref_primary_10_1007_s12026_013_8434_7 crossref_primary_10_1084_jem_20150295 crossref_primary_10_1016_j_imlet_2013_05_003 crossref_primary_10_1016_j_cell_2022_02_021 crossref_primary_10_1038_clpt_2014_136 crossref_primary_10_1002_elsc_201800173 crossref_primary_10_3390_ijms20194719 crossref_primary_10_3389_fimmu_2019_00603 crossref_primary_10_1080_2162402X_2016_1151595 crossref_primary_10_1371_journal_pone_0062070 crossref_primary_10_1158_1078_0432_CCR_17_1283 crossref_primary_10_3390_cells11101639 crossref_primary_10_18632_oncotarget_14124 crossref_primary_10_3390_cancers13051086 crossref_primary_10_1016_j_cell_2013_12_041 crossref_primary_10_3389_fendo_2018_00247 crossref_primary_10_1016_j_carbpol_2019_115295 crossref_primary_10_15252_emmm_201809003 crossref_primary_10_1007_s12307_019_00232_2 crossref_primary_10_1038_bjc_2013_634 crossref_primary_10_1007_s00018_017_2482_4 crossref_primary_10_1158_1078_0432_CCR_17_3862 crossref_primary_10_1111_cas_14639 crossref_primary_10_1111_pin_12355 crossref_primary_10_3389_fimmu_2019_01563 crossref_primary_10_1038_nrclinonc_2015_73 crossref_primary_10_1016_j_canlet_2024_216892 crossref_primary_10_1016_j_jconrel_2021_04_024 crossref_primary_10_1158_0008_5472_CAN_13_2825 crossref_primary_10_2217_imt_2018_0012 crossref_primary_10_1007_s10585_012_9499_8 crossref_primary_10_1158_1078_0432_CCR_12_2693 crossref_primary_10_1016_j_annepidem_2012_03_001 crossref_primary_10_1158_0008_5472_CAN_17_1655 crossref_primary_10_1158_1535_7163_MCT_21_0361 crossref_primary_10_1016_j_biopha_2019_108800 crossref_primary_10_1177_2054270415603909 crossref_primary_10_3390_cancers15194771 crossref_primary_10_1007_s12022_020_09623_4 crossref_primary_10_3390_cancers12010252 crossref_primary_10_1002_jcp_27923 crossref_primary_10_1016_j_mce_2013_06_003 crossref_primary_10_2217_imt_13_102 crossref_primary_10_1038_s41551_020_0524_y crossref_primary_10_1038_s41587_022_01379_y crossref_primary_10_1016_j_jtbi_2013_04_008 crossref_primary_10_1158_2326_6066_CIR_13_0209 crossref_primary_10_1039_D1RA08061J crossref_primary_10_1158_2326_6066_CIR_13_0207 crossref_primary_10_1016_j_biopha_2021_112588 crossref_primary_10_1093_brain_awz241 crossref_primary_10_1172_jci_insight_120422 crossref_primary_10_1007_s12282_021_01231_2 crossref_primary_10_1080_14712598_2022_2098675 crossref_primary_10_2217_imt_2018_0006 crossref_primary_10_1038_nrd_2015_2 crossref_primary_10_4161_cbt_29184 crossref_primary_10_3390_cancers14081999 crossref_primary_10_3389_fimmu_2022_1012730 crossref_primary_10_1158_2326_6066_CIR_17_0345 crossref_primary_10_1016_j_yexcr_2013_03_022 crossref_primary_10_1002_ijc_29125 crossref_primary_10_1158_2159_8290_CD_21_1441 crossref_primary_10_3960_jslrt_18034 crossref_primary_10_1016_j_bbi_2017_10_023 crossref_primary_10_2967_jnumed_111_089177 crossref_primary_10_1158_2326_6066_CIR_13_0217 crossref_primary_10_2174_0929867329666220520121711 crossref_primary_10_1097_PPO_0000000000000007 crossref_primary_10_1111_cas_15751 crossref_primary_10_1186_s13058_021_01448_1 crossref_primary_10_3390_cancers13020178 crossref_primary_10_1016_j_semradonc_2013_05_002 crossref_primary_10_1016_j_bbcan_2013_07_002 crossref_primary_10_1016_j_ccell_2021_08_005 crossref_primary_10_1080_2162402X_2018_1480286 crossref_primary_10_1038_s41523_021_00283_z crossref_primary_10_1182_bloodadvances_2020001966 crossref_primary_10_2217_fon_2020_0967 crossref_primary_10_1038_s41577_019_0271_z crossref_primary_10_3390_cells11182844 crossref_primary_10_1002_adma_202108084 crossref_primary_10_1002_ijc_29376 crossref_primary_10_3389_fimmu_2020_00331 crossref_primary_10_1242_jcs_116392 crossref_primary_10_1158_1078_0432_CCR_20_3955 crossref_primary_10_1002_cyto_a_22867 crossref_primary_10_5306_wjco_v14_i3_117 crossref_primary_10_1098_rsif_2014_1153 crossref_primary_10_1097_PPO_0000000000000246 crossref_primary_10_3390_cells8070747 crossref_primary_10_1016_j_immuni_2012_10_015 crossref_primary_10_1038_s41416_021_01599_0 crossref_primary_10_1038_s41577_024_00998_7 crossref_primary_10_1158_0008_5472_CAN_12_3056 crossref_primary_10_2217_imt_14_48 crossref_primary_10_1073_pnas_1720948115 crossref_primary_10_3390_cells10051073 crossref_primary_10_1038_s41523_019_0135_5 crossref_primary_10_1016_j_biomaterials_2024_122531 crossref_primary_10_1016_j_semcancer_2021_03_038 crossref_primary_10_1158_2159_8290_CD_15_0827 crossref_primary_10_1016_j_trecan_2023_04_001 crossref_primary_10_1158_1078_0432_CCR_14_1860 crossref_primary_10_1371_journal_pone_0069527 crossref_primary_10_1016_j_mam_2011_04_005 crossref_primary_10_3389_fonc_2020_566511 crossref_primary_10_3390_cancers15010172 crossref_primary_10_1126_science_aay1813 crossref_primary_10_3233_CBM_170026 crossref_primary_10_1038_nri3789 crossref_primary_10_3109_02656736_2014_968640 crossref_primary_10_3390_cells10020329 crossref_primary_10_1111_imr_13231 crossref_primary_10_1038_s41598_018_24022_w crossref_primary_10_1038_bjc_2017_205 crossref_primary_10_3390_cells9010051 crossref_primary_10_1016_j_gene_2020_144453 crossref_primary_10_1177_1534735415617014 crossref_primary_10_1155_2022_4290994 crossref_primary_10_1016_j_lfs_2023_122178 crossref_primary_10_1038_ncomms14293 crossref_primary_10_1111_joim_12229 crossref_primary_10_1186_s12935_021_02344_6 crossref_primary_10_1002_path_4723 crossref_primary_10_3389_fimmu_2015_00236 crossref_primary_10_1016_j_oraloncology_2014_11_007 crossref_primary_10_1007_s10911_014_9322_z crossref_primary_10_1007_s12018_013_9146_1 crossref_primary_10_1158_2326_6066_CIR_13_0011 crossref_primary_10_1007_s00262_023_03612_2 crossref_primary_10_1158_0008_5472_CAN_13_3723 crossref_primary_10_3389_fimmu_2022_828386 crossref_primary_10_1042_ETLS20170066 crossref_primary_10_5306_wjco_v7_i5_387 crossref_primary_10_1002_iid3_186 crossref_primary_10_1007_s10238_022_00887_0 crossref_primary_10_1016_j_drudis_2024_103904 crossref_primary_10_1158_1078_0432_CCR_18_3016 crossref_primary_10_1016_j_devcel_2023_06_006 crossref_primary_10_3390_ijms18122732 crossref_primary_10_1007_s00280_018_3594_8 crossref_primary_10_1002_iub_2116 crossref_primary_10_1016_j_imbio_2019_03_002 crossref_primary_10_1038_srep33322 crossref_primary_10_3389_fendo_2020_00058 crossref_primary_10_1002_eji_201344304 crossref_primary_10_1002_JLB_5MA0717_282R crossref_primary_10_1053_j_gastro_2014_02_055 crossref_primary_10_1126_sciadv_abg9518 crossref_primary_10_3389_fimmu_2019_01786 crossref_primary_10_4161_onci_26860 crossref_primary_10_1016_j_ejmech_2015_08_031 crossref_primary_10_1146_annurev_bioeng_062117_121147 crossref_primary_10_1172_jci_insight_120631 crossref_primary_10_1309_AJCPQN8GZ8SILKGN crossref_primary_10_1158_0008_5472_CAN_17_1833 crossref_primary_10_1158_1078_0432_CCR_14_1845 crossref_primary_10_1093_carcin_bgu053 crossref_primary_10_1186_s13046_019_1095_1 crossref_primary_10_1016_j_addr_2021_05_027 crossref_primary_10_1101_cshperspect_a027094 crossref_primary_10_2217_imt_14_13 crossref_primary_10_1016_j_jconrel_2016_12_032 crossref_primary_10_1016_j_bbcan_2012_07_003 crossref_primary_10_1073_pnas_1525349113 crossref_primary_10_1038_s41577_022_00737_w crossref_primary_10_1016_j_expneurol_2019_04_011 crossref_primary_10_1016_j_intimp_2024_112377 crossref_primary_10_3390_cells9010046 crossref_primary_10_3390_ijms22052718 crossref_primary_10_1002_ijc_29181 crossref_primary_10_4103_IJPM_IJPM_201_18 crossref_primary_10_1007_s10911_014_9320_1 crossref_primary_10_1056_NEJMoa1411366 crossref_primary_10_1016_j_it_2019_02_003 crossref_primary_10_1080_2162402X_2022_2120676 crossref_primary_10_1007_s00262_024_03655_z crossref_primary_10_1186_s40425_016_0118_0 crossref_primary_10_1007_s00262_017_2038_3 crossref_primary_10_1016_j_immuni_2014_06_010 crossref_primary_10_1080_2162402X_2019_1581528 crossref_primary_10_1038_s41423_018_0001_7 crossref_primary_10_1097_MD_0000000000002165 crossref_primary_10_1007_s13237_017_0194_7 crossref_primary_10_1007_s40137_019_0242_0 crossref_primary_10_4161_intv_21557 crossref_primary_10_3389_fimmu_2016_00113 crossref_primary_10_1111_febs_15726 crossref_primary_10_1002_jcp_24260 crossref_primary_10_1158_0008_5472_CAN_21_3714 crossref_primary_10_1186_s12885_018_4266_0 crossref_primary_10_2174_1389200224666230110145513 crossref_primary_10_1186_2045_824X_4_14 crossref_primary_10_1186_s12967_017_1139_2 crossref_primary_10_1002_mc_22403 crossref_primary_10_1158_0008_5472_CAN_14_3373 crossref_primary_10_1186_s40425_019_0667_0 crossref_primary_10_3389_fonc_2021_786191 crossref_primary_10_4161_onci_1_1_17885 crossref_primary_10_1126_scitranslmed_aan3311 crossref_primary_10_1038_nature12626 crossref_primary_10_1101_gad_169029_111 crossref_primary_10_1172_JCI164348 crossref_primary_10_1038_nm_2890 crossref_primary_10_1007_s40140_015_0122_9 crossref_primary_10_1038_nm_2652 crossref_primary_10_1186_s12950_022_00307_w crossref_primary_10_1016_j_bcp_2024_116098 crossref_primary_10_1186_s12885_022_09713_y crossref_primary_10_34133_bmef_0006 crossref_primary_10_1016_j_molmed_2013_04_001 crossref_primary_10_1186_s12885_023_10788_4 crossref_primary_10_1007_s10549_014_2896_8 crossref_primary_10_1016_j_ecoenv_2022_113779 crossref_primary_10_1007_s00018_016_2166_5 crossref_primary_10_3389_fonc_2022_852194 crossref_primary_10_1016_j_ejca_2020_11_033 crossref_primary_10_3390_ijms22126526 crossref_primary_10_1177_11795549211035540 crossref_primary_10_20538_1682_0363_2019_1_60_75 crossref_primary_10_3389_fonc_2021_755668 crossref_primary_10_1016_j_ejmech_2022_114782 crossref_primary_10_3390_cancers14020429 crossref_primary_10_1016_j_coi_2013_02_005 crossref_primary_10_1038_s41416_020_0942_3 crossref_primary_10_1002_cnr2_2068 crossref_primary_10_1136_jitc_2021_004029 crossref_primary_10_1016_j_ajpath_2019_07_006 crossref_primary_10_37349_ei_2024_00135 crossref_primary_10_1371_journal_pone_0145197 crossref_primary_10_1101_cshperspect_a028662 crossref_primary_10_3389_fonc_2020_586580 crossref_primary_10_1002_pro6_1191 crossref_primary_10_1038_nature13931 crossref_primary_10_1371_journal_pone_0056045 crossref_primary_10_3389_fonc_2021_629633 crossref_primary_10_1038_bjc_2013_347 crossref_primary_10_1038_s41598_019_55368_4 crossref_primary_10_15252_embr_202256524 crossref_primary_10_1080_15548627_2016_1154244 crossref_primary_10_1126_sciadv_aat7828 crossref_primary_10_3389_fcell_2019_00250 crossref_primary_10_1016_j_semcdb_2016_11_003 crossref_primary_10_1186_s12967_014_0362_3 crossref_primary_10_1136_jitc_2021_004033 crossref_primary_10_1053_j_gastro_2018_08_009 crossref_primary_10_1038_onc_2015_132 crossref_primary_10_1007_s10585_023_10243_5 crossref_primary_10_1016_j_bcp_2015_12_008 crossref_primary_10_1172_JCI67655 crossref_primary_10_1007_s11912_017_0634_1 crossref_primary_10_3390_cancers15092448 crossref_primary_10_1002_ptr_7545 crossref_primary_10_1007_s12213_018_0110_5 crossref_primary_10_1016_j_imlet_2019_03_006 crossref_primary_10_1038_s41556_018_0256_3 crossref_primary_10_1038_nrc3847 crossref_primary_10_1038_bjc_2013_333 crossref_primary_10_1016_j_bbcan_2017_10_003 crossref_primary_10_1007_s00109_014_1124_7 crossref_primary_10_1159_000504055 crossref_primary_10_1007_s10549_016_4041_3 crossref_primary_10_1007_s13194_021_00371_8 crossref_primary_10_1186_s12967_022_03863_0 crossref_primary_10_1016_j_isci_2020_101458 crossref_primary_10_1002_path_5403 crossref_primary_10_18632_oncotarget_20350 crossref_primary_10_3389_fimmu_2019_02215 crossref_primary_10_1158_0008_5472_CAN_16_1201 crossref_primary_10_1158_0008_5472_CAN_14_0067 crossref_primary_10_18632_oncotarget_14913 crossref_primary_10_1016_j_molonc_2012_01_011 crossref_primary_10_1038_nm_3944 crossref_primary_10_1016_j_coi_2015_05_002 crossref_primary_10_1016_j_cell_2016_01_049 crossref_primary_10_1126_scitranslmed_3008763 crossref_primary_10_1016_j_medj_2021_05_001 crossref_primary_10_1097_MD_0000000000035298 crossref_primary_10_1155_2019_5245034 crossref_primary_10_1164_rccm_201508_1545CI crossref_primary_10_3389_fimmu_2016_00559 crossref_primary_10_1016_j_matbio_2023_07_003 crossref_primary_10_1016_j_ccell_2022_05_004 crossref_primary_10_1038_s41392_020_0200_4 crossref_primary_10_1172_JCI76375 crossref_primary_10_3390_cancers14030482 crossref_primary_10_1016_j_placenta_2017_03_001 crossref_primary_10_1016_j_molmed_2020_03_002 crossref_primary_10_3390_medicina59071285 crossref_primary_10_1159_000507314 crossref_primary_10_1002_path_5655 crossref_primary_10_1007_s00262_019_02301_3 crossref_primary_10_1371_journal_pone_0157164 crossref_primary_10_1186_s12885_019_5320_2 crossref_primary_10_3389_fimmu_2015_00516 crossref_primary_10_1158_0008_5472_CAN_14_3587 crossref_primary_10_1038_nrc_2016_54 crossref_primary_10_3390_vaccines11010055 crossref_primary_10_1007_s10555_016_9654_9 crossref_primary_10_1016_j_immuni_2013_06_014 crossref_primary_10_1038_npjbcancer_2015_25 crossref_primary_10_1186_s12943_018_0800_6 crossref_primary_10_1007_s40265_019_01210_0 crossref_primary_10_1038_s41467_017_02732_5 crossref_primary_10_18632_oncotarget_9988 crossref_primary_10_1038_s12276_020_0484_z crossref_primary_10_1158_2159_8290_CD_21_0030 crossref_primary_10_3390_ijms22136995 crossref_primary_10_1073_pnas_1104303108 crossref_primary_10_1097_CM9_0000000000002426 crossref_primary_10_1158_1078_0432_CCR_17_0647 crossref_primary_10_1089_scd_2021_0279 crossref_primary_10_4161_cc_11_4_19358 crossref_primary_10_1016_j_semcancer_2013_05_004 crossref_primary_10_1016_j_tips_2015_08_009 crossref_primary_10_15252_emmm_201606857 crossref_primary_10_1038_icb_2016_126 crossref_primary_10_1186_s12943_023_01725_x crossref_primary_10_3389_fimmu_2022_994319 crossref_primary_10_1016_j_coph_2017_05_007 crossref_primary_10_1007_s10555_016_9643_z crossref_primary_10_3389_fonc_2023_1135456 crossref_primary_10_1126_scitranslmed_aan0026 crossref_primary_10_1158_0008_5472_CAN_12_2731 crossref_primary_10_1182_blood_2012_04_425595 crossref_primary_10_3389_fimmu_2017_02004 crossref_primary_10_1080_08941939_2019_1631411 crossref_primary_10_1158_1078_0432_CCR_16_3122 crossref_primary_10_1016_j_urolonc_2014_02_007 crossref_primary_10_3390_ijms22062907 crossref_primary_10_1186_s12943_021_01317_7 crossref_primary_10_3389_fimmu_2021_643771 crossref_primary_10_1002_path_4103 crossref_primary_10_2174_1568009618666180628102247 crossref_primary_10_1126_sciadv_abc2511 crossref_primary_10_3389_fcell_2016_00027 crossref_primary_10_3389_fimmu_2018_02925 crossref_primary_10_1111_jcmm_18525 crossref_primary_10_1371_journal_pcbi_1007344 crossref_primary_10_1016_j_archoralbio_2018_07_008 crossref_primary_10_1371_journal_pone_0094793 crossref_primary_10_1007_s11912_012_0229_9 crossref_primary_10_1158_2159_8290_CD_12_0480 crossref_primary_10_1371_journal_pone_0095885 crossref_primary_10_1016_j_pharmthera_2019_02_006 crossref_primary_10_1073_pnas_1816410116 crossref_primary_10_1038_s41591_023_02643_7 crossref_primary_10_1186_1742_4682_10_12 crossref_primary_10_1016_j_molmed_2013_06_001 crossref_primary_10_3989_scimar_05012_04A crossref_primary_10_1007_s00262_020_02670_0 crossref_primary_10_3390_pr9010045 crossref_primary_10_1016_j_pharmthera_2019_02_003 crossref_primary_10_1093_carcin_bgac043 crossref_primary_10_1158_0008_5472_CAN_22_1427 crossref_primary_10_1016_j_cell_2013_07_036 crossref_primary_10_1158_0008_5472_CAN_14_1354 crossref_primary_10_1177_1534735415596425 crossref_primary_10_1158_0008_5472_CAN_13_3118 crossref_primary_10_3892_ol_2018_7781 crossref_primary_10_1016_j_cellsig_2014_07_034 crossref_primary_10_1073_pnas_1920377117 crossref_primary_10_1007_s12032_022_01935_1 crossref_primary_10_2217_imt_2016_0135 crossref_primary_10_3389_fimmu_2021_646384 crossref_primary_10_1007_s10555_012_9415_3 crossref_primary_10_1038_s41563_020_00849_5 crossref_primary_10_3390_molecules23081992 crossref_primary_10_1016_j_semcancer_2021_09_003 crossref_primary_10_3389_fonc_2021_639859 crossref_primary_10_1038_nrd4596 crossref_primary_10_1111_febs_15311 crossref_primary_10_2478_sjecr_2018_0018 crossref_primary_10_1016_j_celrep_2015_01_040 crossref_primary_10_1038_nrclinonc_2014_111 crossref_primary_10_1002_hed_25740 crossref_primary_10_4049_jimmunol_1501158 crossref_primary_10_1016_j_adro_2018_07_005 crossref_primary_10_1016_j_cell_2020_03_048 crossref_primary_10_1080_2162402X_2015_1061176 crossref_primary_10_1002_glia_22727 crossref_primary_10_1002_jcla_23335 crossref_primary_10_1016_j_lungcan_2013_02_017 crossref_primary_10_1158_0008_5472_CAN_12_0122 crossref_primary_10_1002_adma_202106350 crossref_primary_10_3390_diagnostics10110865 crossref_primary_10_1242_jcs_186031 crossref_primary_10_1186_s12885_015_1034_2 crossref_primary_10_1039_C8NH00415C crossref_primary_10_1073_pnas_1113744109 crossref_primary_10_3389_fonc_2022_871513 crossref_primary_10_1007_s00262_019_02330_y crossref_primary_10_1016_j_bbcan_2015_06_001 crossref_primary_10_1016_j_ccell_2016_05_017 crossref_primary_10_1038_s42003_020_01362_w crossref_primary_10_1080_02648725_2022_2147661 crossref_primary_10_1111_liv_14098 crossref_primary_10_1111_febs_13125 crossref_primary_10_1016_j_jiac_2020_04_020 crossref_primary_10_3390_ijms22126350 crossref_primary_10_1016_j_bbcan_2015_06_009 crossref_primary_10_1111_bph_14511 crossref_primary_10_1002_advs_202000487 crossref_primary_10_1021_acsbiomaterials_2c00998 crossref_primary_10_1002_glia_22717 crossref_primary_10_18632_oncotarget_14731 crossref_primary_10_1038_s41388_017_0115_x crossref_primary_10_1038_s41568_022_00547_1 crossref_primary_10_1016_j_canlet_2013_10_036 crossref_primary_10_1371_journal_pone_0069182 crossref_primary_10_3390_cancers15051532 crossref_primary_10_1371_journal_pone_0179357 crossref_primary_10_3390_ijms22137239 crossref_primary_10_3389_fphar_2023_1092767 crossref_primary_10_2217_imt_11_178 crossref_primary_10_1016_j_cimid_2018_12_006 crossref_primary_10_1111_febs_14202 crossref_primary_10_1158_0008_5472_CAN_14_3525 crossref_primary_10_1002_JLB_MR0218_056RR crossref_primary_10_1007_s11684_018_0663_7 crossref_primary_10_3390_cancers12051337 crossref_primary_10_1038_s41598_020_62244_z crossref_primary_10_1038_s43018_020_00148_7 crossref_primary_10_1200_JOP_2016_020347 crossref_primary_10_1186_bcr3622 crossref_primary_10_3390_cancers14215317 crossref_primary_10_1016_j_drup_2024_101116 crossref_primary_10_1371_journal_pone_0094357 crossref_primary_10_3389_fmed_2015_00047 crossref_primary_10_1016_j_drup_2020_100715 crossref_primary_10_3389_fimmu_2023_1102778 crossref_primary_10_3390_cancers12123664 crossref_primary_10_1016_j_heliyon_2023_e17582 crossref_primary_10_1186_s40425_018_0435_6 crossref_primary_10_1038_ncomms6275 crossref_primary_10_1016_j_cellimm_2017_09_006 crossref_primary_10_1038_s41573_022_00520_5 crossref_primary_10_1016_j_oraloncology_2016_05_002 crossref_primary_10_1007_s10549_020_05548_y crossref_primary_10_2217_imt_2017_0056 crossref_primary_10_1080_2162402X_2015_1069940 crossref_primary_10_1089_ct_2019_31_383_385 crossref_primary_10_1093_intimm_dxy042 crossref_primary_10_1158_0008_5472_CAN_12_2353 crossref_primary_10_1016_j_molimm_2017_12_003 crossref_primary_10_18632_oncotarget_13660 crossref_primary_10_18632_oncotarget_7955 crossref_primary_10_1016_j_ccell_2015_10_012 crossref_primary_10_1016_j_trecan_2015_11_004 crossref_primary_10_1080_2162402X_2017_1287247 crossref_primary_10_2119_molmed_2011_00217 crossref_primary_10_1038_s41467_018_06008_4 crossref_primary_10_2217_imt_11_157 crossref_primary_10_3389_fphar_2022_967633 crossref_primary_10_15407_fz69_03_083 crossref_primary_10_1038_onc_2017_65 crossref_primary_10_4161_21624011_2014_955696 crossref_primary_10_1136_gutjnl_2015_309193 crossref_primary_10_1016_j_coph_2014_07_004 crossref_primary_10_1021_acs_nanolett_7b01193 crossref_primary_10_1200_JCO_2011_40_9169 crossref_primary_10_1371_journal_pone_0262650 crossref_primary_10_1016_j_ymthe_2018_11_010 crossref_primary_10_1038_onc_2013_357 crossref_primary_10_4161_2162402X_2014_992222 crossref_primary_10_1016_j_bcp_2018_12_016 crossref_primary_10_1631_jzus_B1300264 crossref_primary_10_1016_j_ebiom_2016_02_024 crossref_primary_10_1155_2021_6641384 crossref_primary_10_18632_oncotarget_21066 crossref_primary_10_4161_onci_27158 crossref_primary_10_3389_fonc_2018_00049 crossref_primary_10_3389_fonc_2021_734959 crossref_primary_10_1016_j_ccr_2014_04_026 crossref_primary_10_1158_2326_6066_CIR_14_0232 crossref_primary_10_1073_pnas_1419899111 crossref_primary_10_1177_107327481302000104 crossref_primary_10_2217_mmt_15_37 crossref_primary_10_1007_s10555_021_09974_2 crossref_primary_10_1080_21645515_2023_2269788 crossref_primary_10_18632_oncotarget_11021 crossref_primary_10_1002_eji_201141894 crossref_primary_10_1158_1078_0432_CCR_16_2677 crossref_primary_10_1172_jci_insight_91828 crossref_primary_10_1136_jclinpath_2011_200355 crossref_primary_10_1016_j_imbio_2014_09_011 crossref_primary_10_1158_2159_8290_CD_20_1647 crossref_primary_10_1073_pnas_1812704115 crossref_primary_10_1248_cpb_c21_00705 crossref_primary_10_1158_2326_6066_CIR_16_0309 crossref_primary_10_1111_febs_15333 crossref_primary_10_1111_imm_12976 crossref_primary_10_1016_j_drup_2020_100742 crossref_primary_10_1586_14737140_2015_1042864 crossref_primary_10_1016_j_lfs_2023_121790 crossref_primary_10_1016_j_jconrel_2020_07_001 crossref_primary_10_1186_s40425_019_0610_4 crossref_primary_10_1007_s12094_023_03304_4 crossref_primary_10_1016_j_neuron_2014_02_040 crossref_primary_10_3390_ijms19113333 crossref_primary_10_3390_ijms19030661 crossref_primary_10_1038_s41420_021_00478_0 crossref_primary_10_4049_jimmunol_1301317 crossref_primary_10_1111_jcmm_13977 crossref_primary_10_1155_2014_271940 crossref_primary_10_1016_j_immuni_2021_03_022 crossref_primary_10_1158_0008_5472_CAN_19_1147 crossref_primary_10_1111_his_12407 crossref_primary_10_3389_fimmu_2023_1157291 crossref_primary_10_1159_000351460 crossref_primary_10_3389_fonc_2020_594514 crossref_primary_10_1007_s00262_021_02861_3 crossref_primary_10_1016_j_ajpath_2012_05_012 crossref_primary_10_1080_2162402X_2019_1596004 crossref_primary_10_4161_mabs_27029 crossref_primary_10_1007_s10585_012_9496_y crossref_primary_10_2174_0118761429263841230926014118 crossref_primary_10_3389_fonc_2021_668349 crossref_primary_10_1002_eji_201445300 crossref_primary_10_3390_cancers13133357 crossref_primary_10_1016_j_ijrobp_2020_05_028 crossref_primary_10_1126_science_aaa6204 crossref_primary_10_3390_ijms22052662 crossref_primary_10_1002_jcp_30139 crossref_primary_10_1002_glia_23540 crossref_primary_10_1016_j_addr_2015_11_009 crossref_primary_10_1038_ncb3340 crossref_primary_10_1111_imr_12856 crossref_primary_10_1016_j_bbcan_2015_01_002 crossref_primary_10_1016_j_bbcan_2015_01_003 crossref_primary_10_1038_s41568_019_0209_6 crossref_primary_10_3390_cancers9060068 crossref_primary_10_1158_1078_0432_CCR_13_2576 crossref_primary_10_18632_oncotarget_3828 crossref_primary_10_1155_2015_159269 crossref_primary_10_2139_ssrn_3942126 crossref_primary_10_1038_s41423_024_01134_0 crossref_primary_10_1080_2162402X_2017_1293211 crossref_primary_10_1186_s40425_019_0605_1 crossref_primary_10_1172_JCI84427 crossref_primary_10_1371_journal_pone_0030563 crossref_primary_10_1158_1535_7163_MCT_17_0339 crossref_primary_10_3390_cancers13215318 crossref_primary_10_1016_j_celrep_2020_107731 crossref_primary_10_18632_oncotarget_9383 crossref_primary_10_1021_bc200405d crossref_primary_10_1016_j_nantod_2023_101884 crossref_primary_10_1038_onc_2013_94 crossref_primary_10_3390_cancers14174336 crossref_primary_10_1158_0008_5472_CAN_15_2596 crossref_primary_10_1158_1078_0432_CCR_21_0144 crossref_primary_10_1016_j_trecan_2015_07_008 crossref_primary_10_1039_C5CS00134J crossref_primary_10_1158_1078_0432_CCR_13_1279 crossref_primary_10_4161_onci_19123 crossref_primary_10_1038_s41420_018_0127_5 crossref_primary_10_1371_journal_pmed_1002194 crossref_primary_10_1158_0008_5472_CAN_19_3791 crossref_primary_10_1016_j_pharmthera_2016_09_002 crossref_primary_10_18632_oncotarget_4940 crossref_primary_10_15252_emmm_201606493 crossref_primary_10_1016_j_addr_2022_114239 crossref_primary_10_1088_1742_6596_798_1_012141 crossref_primary_10_1038_s41423_023_01061_6 crossref_primary_10_3892_or_2016_5216 crossref_primary_10_1038_nrd_2018_169 crossref_primary_10_1172_JCI68189 crossref_primary_10_1007_s10528_023_10361_5 crossref_primary_10_1007_s00432_016_2196_2 crossref_primary_10_1007_s00018_023_05017_x crossref_primary_10_1093_neuonc_nox037 crossref_primary_10_1158_2767_9764_CRC_23_0051 crossref_primary_10_1093_jnci_dju230 crossref_primary_10_1186_bcr3226 crossref_primary_10_1186_bcr3469 crossref_primary_10_3389_fimmu_2021_656364 crossref_primary_10_1074_jbc_M116_717868 crossref_primary_10_1158_2767_9764_CRC_22_0043 crossref_primary_10_1158_0008_5472_CAN_15_2528 crossref_primary_10_1038_nrclinonc_2016_217 crossref_primary_10_1038_s41416_019_0441_6 crossref_primary_10_1038_s41556_018_0173_5 crossref_primary_10_1084_jem_20120502 crossref_primary_10_3389_fimmu_2021_702785 crossref_primary_10_1038_nm_3394 crossref_primary_10_1089_ars_2012_5133 crossref_primary_10_3390_v16030372 crossref_primary_10_1158_0008_5472_CAN_13_1816 crossref_primary_10_18632_oncotarget_15326 crossref_primary_10_3390_cancers14092177 crossref_primary_10_1016_j_immuni_2013_02_004 crossref_primary_10_1371_journal_pone_0129123 crossref_primary_10_1016_j_ajpath_2012_06_002 crossref_primary_10_1016_j_ccell_2015_02_015 crossref_primary_10_1016_j_jconrel_2019_09_021 crossref_primary_10_1371_journal_pone_0054302 crossref_primary_10_1038_ncomms12150 crossref_primary_10_1038_s41556_019_0298_1 crossref_primary_10_3389_fphar_2023_1152934 crossref_primary_10_3390_pharmaceutics16010061 crossref_primary_10_1186_s12885_016_2204_6 crossref_primary_10_3389_fcell_2018_00131 crossref_primary_10_1016_j_biopha_2023_114609 crossref_primary_10_1016_j_ejphar_2022_175087 crossref_primary_10_1158_0008_5472_CAN_14_0992 crossref_primary_10_1158_1078_0432_CCR_11_0768 crossref_primary_10_3390_cancers12051314 crossref_primary_10_3390_jcm9123912 crossref_primary_10_1111_vco_12272 crossref_primary_10_1016_j_pharmthera_2022_108274 crossref_primary_10_1002_glia_23975 crossref_primary_10_1155_2016_5230219 crossref_primary_10_3389_fimmu_2024_1302587 crossref_primary_10_1002_jcb_25895 crossref_primary_10_1016_j_bmcl_2018_11_037 crossref_primary_10_1158_0008_5472_CAN_20_0214 crossref_primary_10_1126_scitranslmed_aau9240 crossref_primary_10_1016_j_gendis_2018_05_003 crossref_primary_10_1038_s41598_021_95059_7 crossref_primary_10_1016_j_ccell_2023_02_016 crossref_primary_10_1245_s10434_017_5812_8 crossref_primary_10_1002_ijc_31532 crossref_primary_10_1007_s12672_017_0314_5 crossref_primary_10_1016_j_smim_2015_11_003 crossref_primary_10_1158_2159_8290_CD_22_0475 crossref_primary_10_1038_s41598_023_35985_w crossref_primary_10_1111_ejh_12228 crossref_primary_10_1158_2767_9764_CRC_22_0278 crossref_primary_10_1038_nrclinonc_2015_209 crossref_primary_10_1038_nrd4253 crossref_primary_10_1016_j_ymthe_2023_01_017 crossref_primary_10_1186_s12974_024_03063_1 crossref_primary_10_1016_j_cell_2012_04_042 crossref_primary_10_1158_2326_6066_CIR_20_0499 crossref_primary_10_1158_2159_8290_CD_20_0841 crossref_primary_10_3389_fimmu_2019_01817 crossref_primary_10_1016_j_tins_2021_02_003 crossref_primary_10_1074_jbc_M112_355495 crossref_primary_10_1172_jci_insight_145885 crossref_primary_10_1177_1758835919854238 crossref_primary_10_1186_s41232_022_00208_8 crossref_primary_10_1038_s41523_020_0170_2 crossref_primary_10_1007_s10555_018_9766_5 crossref_primary_10_1016_j_jneuroim_2017_12_016 crossref_primary_10_3389_fonc_2023_1152458 crossref_primary_10_1038_nm_3355 crossref_primary_10_1158_1078_0432_CCR_13_3033 crossref_primary_10_1007_s11033_014_3276_5 crossref_primary_10_1007_s10549_013_2752_2 crossref_primary_10_1155_2019_3980273 crossref_primary_10_1038_s41586_024_07121_9 crossref_primary_10_1051_medsci_20143004021 crossref_primary_10_2967_jnumed_119_230466 crossref_primary_10_3390_cancers13071629 crossref_primary_10_1155_2018_2937012 crossref_primary_10_1146_annurev_pathol_012615_044249 crossref_primary_10_1038_s41416_018_0327_z crossref_primary_10_1016_j_clbc_2019_05_002 crossref_primary_10_1038_s41416_018_0173_z crossref_primary_10_1073_pnas_2107424118 crossref_primary_10_1007_s10549_013_2556_4 crossref_primary_10_1016_S1470_2045_16_00078_4 crossref_primary_10_1155_2016_9012369 crossref_primary_10_1093_neuonc_not082 crossref_primary_10_3390_cancers13153802 crossref_primary_10_3390_ijms20040999 crossref_primary_10_3390_cancers11050633 crossref_primary_10_1016_j_bcp_2013_02_017 crossref_primary_10_12677_ACM_2022_12111544 crossref_primary_10_1038_nri_2017_49 crossref_primary_10_1371_journal_pone_0122912 crossref_primary_10_1136_jitc_2021_003005 crossref_primary_10_1177_10732748231202921 crossref_primary_10_1016_j_canlet_2023_216261 crossref_primary_10_3389_fimmu_2018_02662 crossref_primary_10_1016_j_ccell_2023_12_012 crossref_primary_10_1038_s41467_018_04460_w crossref_primary_10_1007_s40828_022_00163_4 crossref_primary_10_1038_nm_3337 crossref_primary_10_1038_npjbcancer_2016_33 crossref_primary_10_1093_neuonc_nov272 crossref_primary_10_1016_j_ccell_2017_10_003 crossref_primary_10_2147_PGPM_S301303 crossref_primary_10_14694_EdBook_AM_2012_32_186 crossref_primary_10_1016_j_ccell_2017_10_005 crossref_primary_10_4049_jimmunol_2100281 crossref_primary_10_1097_PPO_0000000000000127 crossref_primary_10_1186_s12943_020_01276_5 crossref_primary_10_2217_imt_2018_0156 crossref_primary_10_1016_j_coph_2015_05_008 crossref_primary_10_1097_PPO_0000000000000132 crossref_primary_10_1016_j_nano_2014_04_011 crossref_primary_10_1007_s10549_012_2190_6 crossref_primary_10_1038_s41423_020_00613_4 crossref_primary_10_1016_S0254_6272_14_60095_9 crossref_primary_10_1016_j_xphs_2022_06_005 crossref_primary_10_1016_j_ccell_2017_11_019 crossref_primary_10_1016_j_immuni_2013_03_011 crossref_primary_10_1016_j_ajpath_2017_09_018 crossref_primary_10_1016_j_mehy_2016_01_005 crossref_primary_10_1038_s41523_021_00229_5 crossref_primary_10_4161_onci_27884 crossref_primary_10_1002_adhm_202202609 crossref_primary_10_1038_s41401_018_0056_0 crossref_primary_10_1007_s10555_014_9501_9 crossref_primary_10_1038_nrclinonc_2016_57 crossref_primary_10_1016_j_semcancer_2019_08_019 crossref_primary_10_1155_2018_4786819 crossref_primary_10_3390_cancers13195004 crossref_primary_10_1038_s41467_024_47932_y crossref_primary_10_1073_pnas_1703171114 crossref_primary_10_1016_j_ccell_2023_03_008 crossref_primary_10_4161_onci_26968 crossref_primary_10_1002_ijc_34611 crossref_primary_10_1007_s00280_020_04222_w crossref_primary_10_3390_biomedicines6030087 crossref_primary_10_1073_pnas_2024171118 crossref_primary_10_1084_jem_20190457 crossref_primary_10_1158_2326_6066_CIR_13_0117 crossref_primary_10_1016_j_drup_2014_12_002 crossref_primary_10_4161_cam_20880 crossref_primary_10_31640_LS_2017_1_2_12 crossref_primary_10_1084_jem_20181739 crossref_primary_10_1038_s41467_019_10424_5 crossref_primary_10_1158_1535_7163_MCT_13_0400 crossref_primary_10_2217_imt_2021_0069 crossref_primary_10_1097_PRS_0000000000000807 crossref_primary_10_1016_j_cca_2021_07_011 crossref_primary_10_1016_j_celrep_2022_111384 crossref_primary_10_3389_fsurg_2021_742443 crossref_primary_10_1007_s10555_018_9753_x crossref_primary_10_1371_journal_pone_0104230 crossref_primary_10_1016_j_immuni_2013_10_010 crossref_primary_10_1016_j_nucmedbio_2021_06_005 crossref_primary_10_1016_j_cell_2023_02_020 crossref_primary_10_1084_jem_20160817 crossref_primary_10_1038_nature21409 crossref_primary_10_1089_omi_2017_0174 crossref_primary_10_1002_emmm_201101131 crossref_primary_10_1016_j_cytogfr_2018_01_007 crossref_primary_10_1186_s12885_021_08350_1 crossref_primary_10_3389_fimmu_2014_00127 crossref_primary_10_1021_acs_molpharmaceut_5b00987 crossref_primary_10_1111_imr_13107 crossref_primary_10_1007_s00432_014_1891_0 crossref_primary_10_3390_ijms22073532 crossref_primary_10_1155_2022_9962397 crossref_primary_10_12688_f1000research_129863_1 crossref_primary_10_1371_journal_pone_0267648 crossref_primary_10_1021_acs_molpharmaceut_7b00997 crossref_primary_10_1016_j_isci_2024_108794 crossref_primary_10_7554_eLife_57438 crossref_primary_10_1007_s10555_015_9594_9 crossref_primary_10_1007_s10555_019_09819_z crossref_primary_10_1186_s40001_023_01195_3 crossref_primary_10_1002_jcp_30166 crossref_primary_10_1016_j_semcancer_2020_01_002 crossref_primary_10_3389_fimmu_2017_00229 crossref_primary_10_1158_1078_0432_CCR_12_1420 crossref_primary_10_18632_oncotarget_9340 crossref_primary_10_1134_S2079086418050055 crossref_primary_10_3389_fonc_2021_610303 crossref_primary_10_1530_ERC_18_0284 crossref_primary_10_3390_cells9081785 crossref_primary_10_18632_oncotarget_11823 crossref_primary_10_1631_jzus_B1400352 crossref_primary_10_1158_1078_0432_CCR_20_1696 crossref_primary_10_1038_cr_2012_123 crossref_primary_10_1172_jci_insight_85608 crossref_primary_10_1007_s00262_014_1618_8 crossref_primary_10_1080_09638288_2021_1921861 crossref_primary_10_3389_fimmu_2022_1080501 crossref_primary_10_1111_cas_14328 crossref_primary_10_3389_fimmu_2019_01654 crossref_primary_10_3390_cells12020308 crossref_primary_10_1189_jlb_1MR1016_434RR crossref_primary_10_3389_fimmu_2022_871076 crossref_primary_10_3389_fonc_2021_668731 crossref_primary_10_1158_1078_0432_CCR_15_1135 crossref_primary_10_1080_1120009X_2021_2011661 crossref_primary_10_1007_s00018_011_0863_7 crossref_primary_10_15212_bioi_2020_0002 crossref_primary_10_3389_fonc_2020_00899 crossref_primary_10_1007_s00432_024_05777_4 crossref_primary_10_1016_j_ejmech_2022_114884 crossref_primary_10_1007_s12094_020_02348_0 crossref_primary_10_1016_j_cmet_2019_06_001 crossref_primary_10_1126_science_1232227 crossref_primary_10_18632_oncotarget_7865 crossref_primary_10_1136_jitc_2020_000761 crossref_primary_10_1038_ncomms3516 crossref_primary_10_1016_j_omto_2019_06_003 crossref_primary_10_1007_s40137_017_0194_1 crossref_primary_10_1186_s12935_019_0771_8 crossref_primary_10_1038_s41388_018_0320_2 crossref_primary_10_1158_2159_8290_CD_23_0434 crossref_primary_10_1186_s12943_019_1102_3 crossref_primary_10_1002_mco2_349 crossref_primary_10_3390_ijms22147356 crossref_primary_10_1038_bjc_2013_487 crossref_primary_10_3390_cancers11081080 crossref_primary_10_3390_cancers12092637 crossref_primary_10_1016_j_intimp_2018_05_023 crossref_primary_10_1038_s41420_021_00636_4 crossref_primary_10_1007_s10549_017_4394_2 crossref_primary_10_1016_j_radonc_2019_11_020 crossref_primary_10_1016_j_ctro_2021_03_006 crossref_primary_10_18632_oncotarget_4364 crossref_primary_10_3390_medicina56010015 crossref_primary_10_1186_s13058_023_01717_1 crossref_primary_10_1371_journal_pone_0084859 crossref_primary_10_3389_fimmu_2018_01977 crossref_primary_10_1002_JLB_4RI0818_311R crossref_primary_10_1158_0008_5472_CAN_21_3603 crossref_primary_10_1371_journal_pone_0206223 crossref_primary_10_1007_s00262_013_1427_5 crossref_primary_10_1007_s10555_021_09964_4 crossref_primary_10_15212_bioi_2022_0010 crossref_primary_10_1002_adfm_201905213 crossref_primary_10_1007_s10911_011_9224_2 crossref_primary_10_1371_journal_pone_0095983 crossref_primary_10_1007_s10555_016_9653_x crossref_primary_10_1038_s41568_020_0285_7 crossref_primary_10_1158_1535_7163_MCT_14_0969 crossref_primary_10_18632_oncotarget_8718 crossref_primary_10_3892_ijo_2024_5648 crossref_primary_10_18632_oncotarget_17013 crossref_primary_10_1002_cti2_1108 crossref_primary_10_18632_oncotarget_10895 crossref_primary_10_1080_09553002_2019_1547435 crossref_primary_10_1101_gad_224899_113 crossref_primary_10_1017_erm_2022_8 crossref_primary_10_1038_s41556_019_0303_8 crossref_primary_10_1186_s12974_021_02118_x crossref_primary_10_1016_j_canlet_2013_01_024 crossref_primary_10_1038_nrdp_2016_78 crossref_primary_10_3390_cancers12071722 crossref_primary_10_1038_srep02375 crossref_primary_10_1007_s13346_021_01039_9 crossref_primary_10_3389_fimmu_2020_00297 crossref_primary_10_3390_ijms24087493 crossref_primary_10_1073_pnas_1819473116 crossref_primary_10_1146_annurev_immunol_032712_100008 crossref_primary_10_1038_s42003_021_02375_9 crossref_primary_10_1136_jclinpath_2015_203493 crossref_primary_10_1158_1078_0432_CCR_19_0173 crossref_primary_10_1158_0008_5472_CAN_19_1934 crossref_primary_10_3390_jcm5090076 crossref_primary_10_1515_psr_2019_0058 crossref_primary_10_3390_ijms13089545 crossref_primary_10_3390_ijms24043226 crossref_primary_10_1158_2326_6066_CIR_13_0190 crossref_primary_10_18632_oncotarget_19215 crossref_primary_10_3390_cancers13205099 crossref_primary_10_1016_j_neo_2019_04_004 crossref_primary_10_1038_srep25086 crossref_primary_10_1016_j_pharmthera_2014_11_004 crossref_primary_10_1186_s41182_017_0059_4 crossref_primary_10_1002_1878_0261_12087 crossref_primary_10_1101_gad_314617_118 crossref_primary_10_1007_s43440_023_00480_6 crossref_primary_10_1158_0008_5472_CAN_17_3876 crossref_primary_10_3390_cancers15020376 crossref_primary_10_3389_fimmu_2018_00610 crossref_primary_10_1007_s00262_023_03496_2 crossref_primary_10_1016_j_yexcr_2020_111932 crossref_primary_10_3390_ijms22094802 crossref_primary_10_3892_mmr_2020_11518 crossref_primary_10_1038_nrclinonc_2016_1 crossref_primary_10_1136_gutjnl_2017_313738 crossref_primary_10_1039_D3BM01741A crossref_primary_10_3389_fimmu_2023_1283711 crossref_primary_10_3390_antiox8040103 crossref_primary_10_1038_onc_2017_261 crossref_primary_10_3389_fonc_2014_00366 crossref_primary_10_18632_oncotarget_7671 crossref_primary_10_1007_s12307_012_0123_x crossref_primary_10_1016_j_ccell_2014_09_006 crossref_primary_10_1016_j_semcancer_2012_03_005 crossref_primary_10_1177_1533033820970663 crossref_primary_10_18632_oncotarget_5495 crossref_primary_10_1053_j_gastro_2015_04_010 crossref_primary_10_1016_j_ccell_2014_09_007 crossref_primary_10_1158_1078_0432_CCR_16_3261 crossref_primary_10_1158_0008_5472_CAN_17_3623 crossref_primary_10_1016_j_urolonc_2018_10_010 crossref_primary_10_1128_MCB_00090_14 crossref_primary_10_1186_s13058_016_0740_2 crossref_primary_10_1111_1759_7714_15128 crossref_primary_10_1158_1535_7163_MCT_16_0157 crossref_primary_10_1186_s12935_017_0437_3 crossref_primary_10_3892_ol_2014_2402 crossref_primary_10_1177_17588359231204857 crossref_primary_10_14218_ERHM_2021_00002 crossref_primary_10_1038_s41379_021_00993_6 crossref_primary_10_1158_2159_8290_CD_11_0143 crossref_primary_10_1016_j_gendis_2023_04_023 crossref_primary_10_1016_j_molonc_2013_02_003 crossref_primary_10_1073_pnas_1700455114 crossref_primary_10_1038_nrc_2017_17 crossref_primary_10_3390_cells11233890 crossref_primary_10_1101_cshperspect_a041324 crossref_primary_10_3109_08923973_2014_897727 crossref_primary_10_1016_j_cytogfr_2017_06_009 crossref_primary_10_2147_IJN_S388075 crossref_primary_10_32604_biocell_2022_018023 crossref_primary_10_1111_cas_13650 crossref_primary_10_1053_j_gastro_2013_01_002 crossref_primary_10_1016_j_semcancer_2012_04_006 crossref_primary_10_2217_bmt_13_15 crossref_primary_10_1038_s41467_019_12384_2 crossref_primary_10_1016_j_celrep_2016_05_058 crossref_primary_10_3390_cells10010011 crossref_primary_10_3390_cancers15061897 crossref_primary_10_3390_cancers13164233 crossref_primary_10_1158_2326_6066_CIR_21_0588 crossref_primary_10_1016_j_cels_2018_02_001 crossref_primary_10_18632_oncotarget_7211 crossref_primary_10_1002_cam4_3986 crossref_primary_10_1038_nrclinonc_2013_29 crossref_primary_10_1155_2013_281958 crossref_primary_10_3389_fimmu_2019_00168 crossref_primary_10_1016_j_heliyon_2024_e29332 crossref_primary_10_1038_bjc_2014_446 crossref_primary_10_1111_imm_12459 crossref_primary_10_1007_s10637_021_01084_8 crossref_primary_10_1016_j_clbc_2016_07_004 crossref_primary_10_1016_j_intimp_2022_109569 crossref_primary_10_1016_j_it_2015_02_006 crossref_primary_10_1021_pr501067z crossref_primary_10_1007_s00401_012_1056_7 crossref_primary_10_1016_j_it_2015_02_005 crossref_primary_10_1016_j_it_2015_02_004 crossref_primary_10_1016_j_biopha_2018_01_139 crossref_primary_10_1089_dna_2016_3472 crossref_primary_10_1016_j_canlet_2016_01_043 crossref_primary_10_1016_j_celrep_2016_04_084 crossref_primary_10_1042_EBC20220242 crossref_primary_10_1016_j_cej_2022_138971 crossref_primary_10_1002_eji_201141727 crossref_primary_10_3390_cancers15225484 crossref_primary_10_3389_fonc_2023_1099811 crossref_primary_10_1158_1078_0432_CCR_14_1144 crossref_primary_10_1158_1078_0432_CCR_14_0059 crossref_primary_10_18632_oncotarget_792 crossref_primary_10_1007_s13402_020_00552_2 crossref_primary_10_1101_cshperspect_a026781 crossref_primary_10_1016_j_ejca_2019_01_018 crossref_primary_10_1371_journal_pone_0283003 crossref_primary_10_1038_s41568_022_00546_2 crossref_primary_10_3390_cells8050445 crossref_primary_10_3390_biomedicines11102621 crossref_primary_10_1007_s00262_017_2065_0 crossref_primary_10_4161_onci_28398 crossref_primary_10_1371_journal_pone_0179257 crossref_primary_10_1158_0008_5472_CAN_13_2169 crossref_primary_10_1158_1535_7163_MCT_20_0748 crossref_primary_10_18632_oncotarget_10219 crossref_primary_10_1016_j_ccell_2018_01_011 crossref_primary_10_1136_jitc_2020_001204 crossref_primary_10_1038_s41417_021_00389_3 crossref_primary_10_1080_2162402X_2017_1356142 crossref_primary_10_1186_1479_5876_11_54 crossref_primary_10_3390_cells12182252 crossref_primary_10_1007_s11912_017_0579_4 crossref_primary_10_1111_febs_14343 crossref_primary_10_7554_eLife_43653 crossref_primary_10_1158_0008_5472_CAN_21_1823 crossref_primary_10_1177_1758834012475152 crossref_primary_10_1084_jem_20130875 crossref_primary_10_1186_s13058_023_01628_1 crossref_primary_10_1007_s12026_018_8987_6 crossref_primary_10_4103_jcrt_JCRT_997_20 crossref_primary_10_3389_fimmu_2018_03077 crossref_primary_10_1016_j_xphs_2017_03_031 crossref_primary_10_1002_adfm_202104487 crossref_primary_10_18632_oncotarget_2110 crossref_primary_10_1186_s13059_016_1070_5 crossref_primary_10_4049_jimmunol_1201889 crossref_primary_10_1038_nrc3581 crossref_primary_10_1016_j_immuni_2014_09_014 crossref_primary_10_1016_j_trsl_2022_03_001 crossref_primary_10_1177_1010428318776485 crossref_primary_10_1007_s10549_017_4161_4 crossref_primary_10_1016_j_breast_2016_09_002 crossref_primary_10_1002_cam4_7053 crossref_primary_10_1016_j_trecan_2016_12_007 crossref_primary_10_1158_0008_5472_CAN_12_3981 crossref_primary_10_1021_acs_molpharmaceut_0c00983 crossref_primary_10_1016_j_omtn_2023_102037 crossref_primary_10_3390_cancers15030971 crossref_primary_10_1073_pnas_1215397109 crossref_primary_10_1038_onc_2014_294 crossref_primary_10_1158_0008_5472_CAN_10_4366 crossref_primary_10_1172_jci_insight_123281 crossref_primary_10_1016_j_canlet_2015_09_009 crossref_primary_10_3390_jcm10215196 crossref_primary_10_1007_s10549_019_05195_y crossref_primary_10_1016_j_oraloncology_2014_09_006 crossref_primary_10_1080_08977194_2022_2087520 crossref_primary_10_1080_2162402X_2016_1200771 crossref_primary_10_1111_nyas_12393 crossref_primary_10_1016_j_bioactmat_2022_03_008 crossref_primary_10_1172_JCI151347 crossref_primary_10_1016_j_bbcan_2021_188587 crossref_primary_10_1371_journal_pone_0073310 crossref_primary_10_1158_0008_5472_CAN_13_3043 crossref_primary_10_2217_imt_2017_0171 crossref_primary_10_18632_oncotarget_27707 crossref_primary_10_1155_2022_7099930 crossref_primary_10_1530_ERC_16_0404 crossref_primary_10_1371_journal_pone_0157670 crossref_primary_10_3390_ijms221910665 crossref_primary_10_1111_1348_0421_13041 crossref_primary_10_1002_path_4270 crossref_primary_10_3390_ijms21218102 crossref_primary_10_1073_pnas_1812155116 crossref_primary_10_18632_oncotarget_12694 crossref_primary_10_1038_onc_2014_226 crossref_primary_10_1158_1078_0432_CCR_11_0239 crossref_primary_10_1158_1078_0432_CCR_13_0525 crossref_primary_10_1158_1078_0432_CCR_16_2569 crossref_primary_10_18632_genesandcancer_147 crossref_primary_10_1186_2045_824X_5_20 crossref_primary_10_1158_1078_0432_CCR_15_1912 crossref_primary_10_1158_2326_6066_CIR_22_0030 crossref_primary_10_18632_aging_202802 crossref_primary_10_1016_j_ctrv_2018_08_010 crossref_primary_10_3389_fonc_2023_1308681 crossref_primary_10_1038_bonekey_2014_95 crossref_primary_10_1158_0008_5472_CAN_14_3619 crossref_primary_10_3389_fmed_2022_955599 crossref_primary_10_1016_j_trsl_2017_11_002 crossref_primary_10_1007_s10549_012_2405_x crossref_primary_10_1016_j_bbamcr_2015_11_011 crossref_primary_10_1186_s12885_018_4441_3 crossref_primary_10_1186_s40364_023_00537_x crossref_primary_10_1084_jem_20231263 crossref_primary_10_1093_annonc_mdy032 crossref_primary_10_4161_onci_19456 crossref_primary_10_1021_acs_jmedchem_6b00200 crossref_primary_10_1016_j_ccr_2013_02_013 crossref_primary_10_52679_978_81_952885_6_4_8 crossref_primary_10_1136_gutjnl_2015_310049 crossref_primary_10_1021_acs_molpharmaceut_0c00781 crossref_primary_10_1016_j_semcancer_2014_05_006 crossref_primary_10_18632_oncotarget_24697 crossref_primary_10_1016_j_ccr_2013_01_008 crossref_primary_10_1038_nmat3780 crossref_primary_10_1186_s13046_018_0674_x crossref_primary_10_1158_2159_8290_CD_13_0041 crossref_primary_10_1016_j_coi_2017_01_005 crossref_primary_10_3389_fimmu_2021_650105 crossref_primary_10_3389_fonc_2022_1070243 crossref_primary_10_1172_JCI143765 crossref_primary_10_1186_s13058_014_0488_5 crossref_primary_10_1158_1078_0432_CCR_16_0133 crossref_primary_10_1111_nyas_14377 crossref_primary_10_1186_s12964_020_0530_4 crossref_primary_10_1080_2162402X_2016_1149674 crossref_primary_10_1016_j_intimp_2020_106535 crossref_primary_10_1038_bjc_2013_493 crossref_primary_10_1097_CCO_0000000000000122 crossref_primary_10_1182_blood_2012_11_459347 crossref_primary_10_1097_CCO_0000000000000123 crossref_primary_10_1093_oxfimm_iqad006 crossref_primary_10_3390_cells10040960 crossref_primary_10_1002_adma_202210452 crossref_primary_10_18632_oncotarget_13551 crossref_primary_10_1080_2162402X_2018_1470729 crossref_primary_10_1016_j_coph_2013_05_017 crossref_primary_10_1080_2162402X_2021_1954807 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1158/2159-8274.cd-10-0028 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2159-8290 |
| ExternalDocumentID | 22039576 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: P50CA58207 – fundername: NCI NIH HHS grantid: R01CA140943 – fundername: NCI NIH HHS grantid: R01 CA130980 – fundername: NCI NIH HHS grantid: R01 CA132566 – fundername: NCI NIH HHS grantid: R01 CA130980-02 – fundername: NCI NIH HHS grantid: R01 CA130980-04 – fundername: NCI NIH HHS grantid: R01CA132566 – fundername: NCI NIH HHS grantid: R01 CA140943 – fundername: NCI NIH HHS grantid: R01 CA130980-03 – fundername: NCI NIH HHS grantid: R01 CA130980-01A1 |
| GroupedDBID | --- 53G 5VS AAJMC ADBBV ADCOW AENEX AFHIN ALMA_UNASSIGNED_HOLDINGS BR6 BTFSW CGR CUY CVF EBS ECM EIF EJD H13 KQ8 NPM OK1 RCR RHF RHI |
| ID | FETCH-LOGICAL-c645t-ed8947e3dcbda4f502771b62ade3d339b32a655a852e7caea5a58ebd78675e7a2 |
| IngestDate | Sat Sep 28 07:50:10 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c645t-ed8947e3dcbda4f502771b62ade3d339b32a655a852e7caea5a58ebd78675e7a2 |
| OpenAccessLink | https://cancerdiscovery.aacrjournals.org/content/candisc/1/1/54.full.pdf |
| PMID | 22039576 |
| ParticipantIDs | pubmed_primary_22039576 |
| PublicationCentury | 2000 |
| PublicationDate | 2011-06-01 |
| PublicationDateYYYYMMDD | 2011-06-01 |
| PublicationDate_xml | – month: 06 year: 2011 text: 2011-06-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cancer discovery |
| PublicationTitleAlternate | Cancer Discov |
| PublicationYear | 2011 |
| References | 18947395 - Breast Cancer Res. 2008;10(5):R89 20005149 - Cytokine Growth Factor Rev. 2010 Feb;21(1):41-8 16169465 - Cancer Cell. 2005 Sep;8(3):197-209 18160686 - N Engl J Med. 2007 Dec 27;357(26):2666-76 20338029 - BMC Cancer. 2010;10:112 1334964 - J Cell Biochem. 1992 Dec;50(4):350-6 19188147 - Clin Cancer Res. 2009 Feb 1;15(3):778-87 16124834 - PLoS Med. 2005 Sep;2(9):e284 17602071 - J Clin Oncol. 2007 Jul 1;25(19):2650-5 19887542 - Mol Cancer Ther. 2009 Nov;8(11):3151-61 19118225 - Eur Respir J. 2009 Jan;33(1):118-26 17545580 - Cancer Res. 2007 Jun 1;67(11):5064-6 20841473 - Cancer Res. 2010 Oct 1;70(19):7465-75 19029450 - Blood. 2008 Dec 1;112(12):4364-5 20829329 - Clin Cancer Res. 2010 Nov 1;16(21):5351-61 20371344 - Cell. 2010 Apr 2;141(1):39-51 19815678 - Blood. 2009 Oct 8;114(15):3135-6 19197294 - Nat Rev Immunol. 2009 Mar;9(3):162-74 19647220 - Cancer Cell. 2009 Aug 4;16(2):91-102 17942936 - Cancer Res. 2007 Oct 15;67(20):10019-26 19668347 - PLoS One. 2009;4(8):e6562 20811059 - Invest Ophthalmol Vis Sci. 2011 Feb;52(2):643-50 20220182 - N Engl J Med. 2010 Mar 11;362(10):875-85 20299316 - Clin Breast Cancer. 2010 Apr;10(2):160-3 18997773 - Nature. 2008 Dec 11;456(7223):814-8 11257139 - J Exp Med. 2001 Mar 19;193(6):727-40 17114237 - Cancer Res. 2006 Dec 1;66(23):11238-46 18671239 - Cancer. 2008 Sep 15;113(6):1387-95 19498003 - Am J Pathol. 2009 Jul;175(1):334-41 19765725 - J Surg Res. 2011 May 15;167(2):e211-9 16896004 - J Clin Oncol. 2006 Sep 10;24(26):4236-44 19949854 - Breast Cancer Res Treat. 2010 Sep;123(2):397-404 11553815 - Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74 19934330 - Cancer Res. 2009 Dec 15;69(24):9498-506 20504948 - J Leukoc Biol. 2010 Sep;88(3):495-505 20005150 - Cytokine Growth Factor Rev. 2010 Feb;21(1):3-10 18451232 - Clin Cancer Res. 2008 May 1;14(9):2681-9 8543387 - Int J Cancer. 1996 Jan 3;65(1):112-9 20525890 - J Immunol. 2010 Jul 1;185(1):203-10 20842526 - Breast Cancer Res Treat. 2011 Aug;128(3):703-11 18438415 - Nat Med. 2008 May;14(5):518-27 20405169 - Cancer Metastasis Rev. 2010 Jun;29(2):309-16 19443701 - Am J Pathol. 2009 Jun;174(6):2347-56 8840975 - Cancer Res. 1996 Oct 15;56(20):4625-9 21215706 - Cancer Cell. 2011 Jan 18;19(1):31-44 18287029 - Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3041-6 15894262 - Cancer Cell. 2005 May;7(5):411-23 15466195 - Cancer Res. 2004 Oct 1;64(19):7022-9 1312220 - Mol Cell Biol. 1992 Mar;12(3):954-61 14578209 - Am J Pathol. 2003 Nov;163(5):2113-26 12829800 - Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23 19015530 - Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18895-900 18509509 - Mol Oncol. 2007 Dec;1(3):288-302 16168663 - Semin Cancer Biol. 2006 Feb;16(1):53-65 19282852 - Nat Rev Immunol. 2009 Apr;9(4):259-70 10963602 - Nature. 2000 Aug 17;406(6797):747-52 20138013 - Cancer Cell. 2010 Feb 17;17(2):121-34 20220849 - Nature. 2010 Mar 11;464(7286):302-5 |
| References_xml | |
| SSID | ssj0000494507 |
| Score | 2.5995207 |
| Snippet | Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 54 |
| SubjectTerms | Aged Animals Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - metabolism CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cohort Studies Disease-Free Survival Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - metabolism Female Follow-Up Studies Humans Leukocytes - drug effects Leukocytes - immunology Leukocytes - metabolism Lung Neoplasms - drug therapy Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - secondary Macrophage Colony-Stimulating Factor - immunology Macrophage Colony-Stimulating Factor - metabolism Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - metabolism Mice Neoplasm Metastasis Paclitaxel - pharmacology Prognosis Receptor, Macrophage Colony-Stimulating Factor - immunology Receptor, Macrophage Colony-Stimulating Factor - metabolism Signal Transduction - drug effects Signal Transduction - immunology Survival Rate Tumor Microenvironment - immunology |
| Title | Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22039576 |
| Volume | 1 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwELZakBAvExu_NjbkB96mjNSx4-QR2k57YH2AIfE22fFFE7C2atOp---5i-OkW0HAw16syJasKPflfL777o6xd3hixLqwSaSNxguKTF1kpdSRpVLlqbVJmVPu8NkXPfmWjcZy3OuFxiTd3INKGudQ1pQ5-x_SbjfFCXxGmeOIUsfxn-T-CVY_ZsVtBZ4tDmsys-cLisdUy2NLHPSKqF4FlXFeoaK4aaoF0AnnHYM_b48XvkU9UFChJtHWHTZQwNdNxtadaPDQb0cZvsQIbb30I5ggAGctd75r5PVxgQre-15H3hfZRn5gfYVH5HfPOas6lsDnVVmGIMkigNp1DtjAqzqBWq-hkZFHFL-9o4S3sOYVqq8wva3nFeUuNDtpeVK4mmAX-0TzDTHPr2s5CxFTQDL9--q96tthqc_6aEuRuT08b314VFsH7ekmIxPf6f3v3ojqTTe73Lu71DbMxTO201w--AePml3Wg-kee3Le0Cues6sWPLwDDw_g4R483IOHB_BwBA_fBA9vwcMDeHg145vgecG-no4vhmdR04ojKlKpqghclksNiSusM7JUFPkf2FQYh3NJkttEmFQpkykBujBglFEZWKczvJCCNuIlezSdTeE14wMhLOqADKjDi9SxLaSigraxcLkZZOk-e-W_0eXc11u5DF_v4I8rb9jTDmqH7HGJPzMcsf7Srd7WIvsFP8dthw |
| link.rule.ids | 782 |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Leukocyte+complexity+predicts+breast+cancer+survival+and+functionally+regulates+response+to+chemotherapy&rft.jtitle=Cancer+discovery&rft.au=DeNardo%2C+David+G&rft.au=Brennan%2C+Donal+J&rft.au=Rexhepaj%2C+Elton&rft.au=Ruffell%2C+Brian&rft.date=2011-06-01&rft.eissn=2159-8290&rft.volume=1&rft.issue=1&rft.spage=54&rft_id=info:doi/10.1158%2F2159-8274.cd-10-0028&rft_id=info%3Apmid%2F22039576&rft_id=info%3Apmid%2F22039576&rft.externalDocID=22039576 |