Association between serum total antioxidant capacity and mortality in severe septic patients

• Published in: Journal of critical care Vol. 30; no. 1; pp. 217.e7 - 217.e12
• Main Authors: Lorente, Leonardo, MD, PhD, Martín, María M., MD, PhD, Almeida, Teresa, MD, PhD, Abreu-González, Pedro, MD, PhD, Ferreres, José, MD, PhD, Solé-Violán, Jordi, MD, PhD, Labarta, Lorenzo, PhD, Díaz, César, PhD, Jiménez, Alejandro, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-02-2015; Elsevier Limited
• Subjects: Adult; Aged; Antioxidants; Antioxidants - metabolism; Area Under Curve; Benzothiazoles - metabolism; Biomarkers - blood; Chronic obstructive pulmonary disease; Colleges & universities; Confidence intervals; Critical Care; Diabetes; Female; Humans; Infections; Intensive Care Units; Lipids; Male; Middle Aged; Mortality; Myoglobin - metabolism; Outcome; Oxidative stress; Oxidative Stress - physiology; Physiology; Prognosis; Prospective Studies; Regression Analysis; ROC Curve; Sepsis; Sepsis - blood; Sepsis - mortality; Spain; Sulfonic Acids - metabolism; Survivors; TAC; Spain; Sepsis; Mortality; Outcome; TAC
• ISSN: 0883-9441; 1557-8615
• DOI: 10.1016/j.jcrc.2014.09.012

Abstract Purpose Total antioxidant capacity (TAC) in severe septic patients has been analyzed in few studies with limited number of subjects. In addition, no association between TAC serum levels and mortality in patients with sepsis has been investigated. We aimed at assessing a possible relationship between TAC serum levels and mortality using a large cohort of patients with severe sepsis. Methods We performed an observational, prospective, multicenter study in 6 Spanish intensive care units. Serum levels of TAC were measured in a total of 213 patients with severe sepsis. End point was 30-day mortality. Results Nonsurviving septic patients (n = 75) showed higher serum TAC levels ( P = .006) than survivors (n = 138). Cox regression analysis showed that TAC serum levels were associated with 30-day survival (hazard ratio = 1.50, 95% confidence interval = 1.16-1.94, P = .002). Receiver operating characteristic analysis showed that the area under curve of TAC serum levels to predict 30-day survival was 0.61 (95% confidence interval = 0.545-0.680, P = .04). Conclusions The most relevant and new findings of our study, the largest cohort of septic patients providing data on circulating TAC levels so far, were that serum TAC levels are associated with mortality and could be used as biomarker to outcome prediction in severe septic patients.