Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer from normal tissue. However, a major challenge remains in identifying tractable molecular targets that hypoxic cancer cells depend on for survival. Here, we used SILAC‐based proteomics to identify the orphan...

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Bibliographic Details
Published in:	EMBO molecular medicine Vol. 10; no. 11; pp. 1 - n/a
Main Authors:	Greenhough, Alexander, Bagley, Clare, Heesom, Kate J, Gurevich, David B, Gay, David, Bond, Mark, Collard, Tracey J, Paraskeva, Chris, Martin, Paul, Sansom, Owen J, Malik, Karim, Williams, Ann C
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-11-2018 EMBO Press John Wiley and Sons Inc Springer Nature
Subjects:	Adaptation Adaptation, Physiological - drug effects Adaptor Proteins, Signal Transducing - metabolism Animals Antigens, Neoplasm - metabolism Apoptosis Basic Helix-Loop-Helix Transcription Factors - metabolism Cancer Cancer therapies Carbonic Anhydrase IX - metabolism Cell Hypoxia - drug effects Cell Line, Tumor Cell survival Cell Survival - drug effects Doxycycline - pharmacology EMBO03 EMBO46 Epithelium GPRC5A HIF Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Ischemia Mice, Inbred C57BL Models, Biological Neoplasms - genetics Neoplasms - pathology Oxygen Phosphoproteins - metabolism Physiology Proteins Proteomics Receptors, G-Protein-Coupled - metabolism Research Article RhoA protein Signal transduction Signal Transduction - drug effects Solid tumors Transcription Factors Transcription, Genetic - drug effects YAP YAP-Signaling Proteins Yes-associated protein Zebrafish hypoxia YAP cancer GPRC5A HIF
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