Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD). Populations at risk for AD show altered brain activity in the default mode network (DMN) before cognitive dysfunction. We evaluated this brain pattern in T2DM patients. We compared T2DM patients (n = 10, age = 56 ± 2.2 year...

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Bibliographic Details
Published in:	Diabetes (New York, N.Y.) Vol. 61; no. 9; pp. 2375 - 2379
Main Authors:	MUSEN, Gail, JACOBSON, Alan M, BOLO, Nicolas R, SIMONSON, Donald C, SHENTON, Martha E, MCCARTNEY, Richard L, FLORES, Veronica L, HOOGENBOOM, Wouter S
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Diabetes Association 01-09-2012
Subjects:	Aged Alzheimer's disease Analysis Atrophy Biological and medical sciences Brain Brain - physiopathology Brain mapping Cognition Cognition & reasoning Cognitive ability Complications Diabetes Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Executive function Female Frontal Lobe - physiopathology Glucose Hippocampus - anatomy & histology Hippocampus - physiopathology Homeostasis Humans Insulin Resistance Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Models, Biological Software Temporal Lobe - physiopathology Thalamus - physiopathology Type 2 diabetes Endocrinopathy Type 2 diabetes Metabolic diseases Central nervous system Encephalon
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