Cytochrome P450 2D6 Polymorphism Is a Molecular Genetic Marker of Liver Cirrhosis Progression

Patients with infectious viral or toxic cirrhosis of the liver participated in complex clinical pathomorphological and molecular-genetic study aimed at the search for markers of predisposition to accelerated liver fibrosis, in which the xenobiotic biotransformation system is involved. The results de...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 152; no. 5; pp. 633 - 636
Main Authors:	Nepomnyashchikh, D. L., Vavilin, V. A., Aidagulova, S. V., Makarova, S. I., Karavaeva, Yu. Yu, Shchepotina, E. G., Postnikova, O. A., Nokhrina, Zh. V., Vinogradova, E. V., Lyakhovich, V. V.
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-03-2012 Springer Springer Nature B.V
Subjects:	Adult Aged Biomedical and Life Sciences Biomedicine biotransformation Cell Biology Cirrhosis CYP2D6 protein Cytochrome P-450 Cytochrome P-450 CYP2D6 - genetics Cytochrome P450 Development and progression Disease Progression European Continental Ancestry Group Female Fibrosis Gene polymorphism Genetic aspects Genetic Markers Genetic Predisposition to Disease Hepacivirus - physiology Hepatitis B - complications Hepatitis B - genetics Hepatitis B - pathology Hepatitis B - virology Hepatitis B virus - physiology Hepatitis C - complications Hepatitis C - genetics Hepatitis C - pathology Hepatitis C - virology Hepatitis, Alcoholic - complications Hepatitis, Alcoholic - genetics Hepatitis, Alcoholic - pathology Heterozygote Homozygote Humans Internal Medicine Laboratory Medicine Liver Liver - enzymology Liver - pathology Liver - virology Liver cirrhosis Liver Cirrhosis - etiology Liver Cirrhosis - genetics Liver Cirrhosis - pathology Liver Cirrhosis - virology Male Middle Aged Morphology and Pathomorphology Pathology Physiological aspects Polymorphism, Single Nucleotide Siberia Xenobiotics Siberia cytochrome P450 2D6 polymorphism liver cirrhosis
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Summary:	Patients with infectious viral or toxic cirrhosis of the liver participated in complex clinical pathomorphological and molecular-genetic study aimed at the search for markers of predisposition to accelerated liver fibrosis, in which the xenobiotic biotransformation system is involved. The results demonstrate association between CYP2D6 (1846 G/A) genotype and rapid cirrhosis development and indicate the necessity of studying the mechanisms underlying this association.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-012-1595-x