Variant in the sequence of the LINGO1 gene confers risk of essential tremor

• Published in: Nature genetics Vol. 41; no. 3; pp. 277 - 279
• Main Authors: Stefansson, Kari, Stefansson, Hreinn, Steinberg, Stacy, Petursson, Hjorvar, Gustafsson, Omar, Gudjonsdottir, Iris H, Jonsdottir, Gudrun A, Palsson, Stefan T, Jonsson, Thorlakur, Saemundsdottir, Jona, Bjornsdottir, Gyda, Böttcher, Yvonne, Thorlacius, Theodora, Haubenberger, Dietrich, Zimprich, Alexander, Auff, Eduard, Hotzy, Christoph, Testa, Claudia M, Miyatake, Lisa A, Rosen, Ami R, Kristleifsson, Kristleifur, Rye, David, Asmus, Friedrich, Schöls, Ludger, Dichgans, Martin, Jakobsson, Finnbogi, Benedikz, John, Thorsteinsdottir, Unnur, Gulcher, Jeffrey, Kong, Augustine
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-03-2009; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Animals; Austria; Beta blockers; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; brief-communication; Cancer Research; Essential Tremor - genetics; Fundamental and applied biological sciences. Psychology; Gene Frequency; Gene Function; Genetic aspects; Genetic linkage; Genetic Predisposition to Disease; Genetic variation; Genetics of eukaryotes. Biological and molecular evolution; Genetics, Population; Genome-Wide Association Study; Germany; Human Genetics; Humans; Iceland; Linkage Disequilibrium; Medical research; Medical sciences; Membrane Proteins - genetics; Mice; Mice, Knockout; Nerve Tissue Proteins - genetics; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Polymorphism, Single Nucleotide - physiology; Risk Factors; Studies; Tremor; United States; Austria; United States; Germany; Iceland; Variant; Nervous system diseases; Gene; Tremor; Risk; Neurological disorder; Involuntary movement
• ISSN: 1061-4036; 1546-1718
• DOI: 10.1038/ng.299

We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 × 10−9, odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse knockout models highlights the potential role of LINGO1 in the pathophysiology of essential tremor.