MN1 overexpression is an important step in the development of inv(16) AML

The gene encoding the transcriptional co-activator MN1 is the target of the reciprocal chromosome translocation (12;22)(p13;q12) in some patients with acute myeloid leukemia (AML). In addition, expression array analysis showed that MN1 was overexpressed in AML specified by inv(16), in some AML overe...

Full description

Saved in:

Bibliographic Details
Published in:	Leukemia Vol. 21; no. 8; pp. 1679 - 1690
Main Authors:	CARELLA, C, BONTEN, J, GROSVELD, G. C, SIRMA, S, KRANENBURG, T. A, TERRANOVA, S, KLEIN-GELTINK, R, SHURTLEFF, S, DOWNING, J. R, ZWARTHOFF, E. C, LIU, P. P
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 01-08-2007 Nature Publishing Group
Subjects:	Abnormalities Acute Disease Acute myeloid leukemia Animals Biological and medical sciences Bone marrow Bone Marrow Transplantation Care and treatment Cell culture Cells, Cultured Chromosome Inversion Chromosome translocations Chromosomes, Human, Pair 16 - genetics Development and progression Female Flow Cytometry Gene Expression Regulation, Neoplastic - physiology Genes Genetic aspects Hematologic and hematopoietic diseases Humans Leukemia Leukemia, Myeloid - etiology Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical prognosis Medical sciences Meningioma Mice Mice, Transgenic Mimicry Myelocytic leukemia Myeloproliferative diseases Myeloproliferative Disorders - etiology Myeloproliferative Disorders - metabolism Myeloproliferative Disorders - pathology Nonlymphoid leukemia Oncogene Proteins - genetics Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Patients Physiological aspects Proteins Survival Rate Transcription Translocation Translocation, Genetic - genetics Transplants Transplants & implants Tumor suppressor genes United States > US AML inv MN1 Hematology Gene overexpression Malignant hemopathy CBFβ-SMMHC Acute myelocytic leukemia
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!