Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an exuberant inflammatory desmoplastic response. The PDAC microenvironment is complex, containing both pro- and antitumorigenic elements, and remains to be fully characterized. Here, we show that sensory neurons, an under-studied cohort of...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 11; pp. 3078 - 3083
Main Authors:	Saloman, Jami L., Albers, Kathryn M., Li, Dongjun, Hartman, Douglas J., Crawford, Howard C., Muha, Emily A., Rhim, Andrew D., Davis, Brian M.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 15-03-2016 National Acad Sciences
Subjects:	Adenocarcinoma in Situ - pathology Adenocarcinoma in Situ - physiopathology Afferent Pathways Animals Animals, Newborn Biological Sciences Capsaicin - administration & dosage Capsaicin - pharmacology Capsaicin - therapeutic use Carcinoma, Pancreatic Ductal - etiology Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - physiopathology Carcinoma, Pancreatic Ductal - prevention & control Carcinoma, Pancreatic Ductal - therapy Cells Ceruletide - toxicity Denervation Disease Progression Female Ganglia, Sympathetic - physiopathology Genes, ras Humans Male Mice Mice, Inbred C57BL Mice, Transgenic Myelitis - complications Myelitis - genetics Myelitis - physiopathology Neoplasm Invasiveness Nervous system Neurons Pancreas Pancreas - innervation Pancreatic Neoplasms - etiology Pancreatic Neoplasms - pathology Pancreatic Neoplasms - physiopathology Pancreatic Neoplasms - prevention & control Pancreatic Neoplasms - therapy Pancreatitis - chemically induced Pancreatitis - complications Pancreatitis - physiopathology Precancerous Conditions - chemically induced Precancerous Conditions - complications Precancerous Conditions - physiopathology Rodents Sensory Receptor Cells - drug effects Sensory Receptor Cells - physiology Spinal Cord - physiopathology Spinothalamic Tracts - physiopathology Thoracic Vertebrae Tumors sensory neuron tumorigenesis inflammation PanIN pancreatic ductal adenocarcinoma
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