Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation

Background Schistosomiasis, a chronic helminth infection, elicits distinct immune responses within the host, ranging from an initial TH 1 and subsequent TH 2 phase to a regulatory state, and is associated with dampened allergic reactions within the host. Objective We sought to evaluate whether non-t...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 134; no. 6; pp. 1271 - 1279.e10
Main Authors:	Straubinger, Kathrin, PhD, Paul, Sabine, VTA, Prazeres da Costa, Olivia, MSc, Ritter, Manuel, PhD, Buch, Thorsten, PhD, Busch, Dirk H., MD, Layland, Laura E., PhD, Prazeres da Costa, Clarissa U., MD
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-12-2014 Elsevier Elsevier Limited
Subjects:	Allergens - immunology allergic airway inflammation Allergy and Immunology Androgens Animals Animals, Newborn Antigens Arrays Biological and medical sciences Biosynthesis Cytokines - genetics Cytokines - immunology Diabetes Disease Susceptibility - immunology Epidemiology. Vaccinations Female Females Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression General aspects Heparan sulfate hygiene hypothesis Immune system Immunoglobulin E - immunology Immunopathology in utero programming Infections Infectious diseases Maternal helminth infection Medical sciences Metabolism Mice, Inbred BALB C Mice, Transgenic offspring Ovalbumin - immunology Placenta Pneumonia - immunology Pregnancy Pregnancy - immunology Respiratory Hypersensitivity - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Schistosoma Schistosomiasis mansoni - immunology Serotonin offspring Ovalbumin PAS hygiene hypothesis Maternal helminth infection pregnancy Treg AAI Intracellular cytokine staining Soluble egg antigen allergic airway inflammation BAL SEA in utero programming Aluminium hydroxide (Al[OH] 3) Bronchoalveolar lavage Reg Periodic acid–Schiff ICS Regulatory T OVA Regulatory state Alum Allergy Immunopathology Immune response Programming Inflammation Parasitosis Respiratory system Helminthiasis In utero Hypothesis Infection Pregnancy Respiratory tract Progeny Sensitivity Immunology Mother Female Hygiene
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