Regulation of Inflammation in Autoimmune Disease

• Published in: Journal of immunology research Vol. 2019; pp. 7403796 - 2
• Main Authors: Duan, Lihua, Rao, Xiaoquan, Sigdel, Keshav Raj
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 01-01-2019; Hindawi Limited
• Subjects: Amnion; Antigen-presenting cells; Autoimmune diseases; Cell activation; Chronic illnesses; Cytokines; Diabetes mellitus; Disease; Epigenetics; Experimental allergic encephalomyelitis; Gene expression; Gout; Immune response; Immune system; Immunology; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory response; Intestine; Lymphocytes; Lymphocytes T; Mesenchyme; Myelination; Pathogenesis; Peptides; Rheumatoid arthritis; Systemic lupus erythematosus
• ISSN: 2314-8861; 2314-7156
• DOI: 10.1155/2019/7403796

Recently, increasing evidences have shown that the abnormal inflammatory response is closely associated with many chronic diseases, especially in autoimmune diseases, including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), gout, and diabetes [1–3]. The costimulatory molecule dyad interaction between T cells and APCs has been linked to the development of abnormal immune response [6]. [...]inhibition of costimulatory molecule interaction has been suggested to result in impaired T cell activation. J. Sun et al. demonstrated that human amnion mesenchymal cells (hAMC) could attenuate the inflammation and promote the remyelination in EAE mice, which might be a promising cell source for the therapy of MS. Epigenetic mechanism has been implicated in the development and progression of many autoimmune diseases [11].