INHIBITION OF REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS BY A HETEROPOLYOXOTUNGSTATE (PM-19)

A Keggin polyoxotungstate PM-19 K7[PTi2W10O40]·6H2O was found to be a potent inhibitor of the replication of human immunodeficiency virus (HIV), which causes acquired immunodeficiency syntdrome (AIDS), in OKT4+ cells. In contrast, the effect of HPA 23 (NH4)17Na[NaSb9W21O86], an inhibitor of reverse...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 38; no. 1; pp. 285 - 287
Main Authors:	INOUYE, Yoshio, TAKE, Yukinori, TOKUTAKE, Yoshiki, YOSHIDA, Tetsuya, YAMAMOTO, Akihiro, YAMASE, Toshihiro, NAKAMURA, Shoshiro
Format:	Journal Article
Language:	English
Published:	Tokyo The Pharmaceutical Society of Japan 01-01-1990 Maruzen
Subjects:	acquired immunodeficiency syndrome (AIDS) AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents antiviral agent Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences heteropolyoxotungstate HIV - drug effects HIV - physiology human immunodeficiency virus (HIV) Keggin structure Medical sciences Pharmacology. Drug treatments Polymers - pharmacology Tungsten - pharmacology Tungsten Compounds Virus Replication - drug effects Virus Heteropolysalt In vitro replication Retroviridae Microorganism culture Lentivirinae Inhibition Human immunodeficiency virus
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Summary:	A Keggin polyoxotungstate PM-19 K7[PTi2W10O40]·6H2O was found to be a potent inhibitor of the replication of human immunodeficiency virus (HIV), which causes acquired immunodeficiency syntdrome (AIDS), in OKT4+ cells. In contrast, the effect of HPA 23 (NH4)17Na[NaSb9W21O86], an inhibitor of reverse transcriptase of HIV, was not significant.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.38.285