Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland

The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin a...

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Bibliographic Details
Published in:	PLoS biology Vol. 10; no. 6; p. e1001347
Main Authors:	González, Sergio, Moreno-Delgado, David, Moreno, Estefanía, Pérez-Capote, Kamil, Franco, Rafael, Mallol, Josefa, Cortés, Antoni, Casadó, Vicent, Lluís, Carme, Ortiz, Jordi, Ferré, Sergi, Canela, Enric, McCormick, Peter J
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 19-06-2012 Public Library of Science (PLoS)
Subjects:	Adenosina Adenosine Adrenaline receptors Animals Biology CHO Cells Circadian Rhythm - physiology Colleges & universities Cricetinae Dopamine Dopamine - metabolism Experiments Glàndula pineal HEK293 Cells Humans Male Melatonin Melatonin - biosynthesis Melatonina Phosphorylation Pineal gland Pineal Gland - metabolism Rats Receptors adrenèrgics Receptors, Adrenergic, alpha-1 - genetics Receptors, Adrenergic, alpha-1 - metabolism Receptors, Adrenergic, beta-1 - genetics Receptors, Adrenergic, beta-1 - metabolism Receptors, Dopamine D4 - genetics Receptors, Dopamine D4 - metabolism Retina Serotonin Serotonin - biosynthesis Transfection Cricetinae Melatonin Dopamine Serotonin Pineal Gland Receptors, Adrenergic, alpha-1 Humans Rats Male Circadian Rhythm Animals Transfection Receptors, Dopamine D4 Receptors, Adrenergic, beta-1 HEK293 Cells CHO Cells
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