In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

Objectives The aim of this study was to test whether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macrophages improves infarct healing and attenuates post–myocardial infarction (MI) remodeling. Background In healing wounds, the M1 toward M2 macrophage phenot...

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Published in:	Journal of the American College of Cardiology Vol. 63; no. 15; pp. 1556 - 1566
Main Authors:	Courties, Gabriel, PhD, Heidt, Timo, MD, Sebas, Matthew, BS, Iwamoto, Yoshiko, BS, Jeon, Derrick, MS, Truelove, Jessica, BS, Tricot, Benoit, MS, Wojtkiewicz, Greg, MS, Dutta, Partha, PhD, Sager, Hendrik B., MD, Borodovsky, Anna, PhD, Novobrantseva, Tatiana, PhD, Klebanov, Boris, PhD, Fitzgerald, Kevin, PhD, Anderson, Daniel G., PhD, Libby, Peter, MD, Swirski, Filip K., PhD, Weissleder, Ralph, MD, PhD, Nahrendorf, Matthias, MD, PhD
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 22-04-2014 Elsevier Elsevier Limited
Subjects:	Animals Atherosclerosis Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Disease Models, Animal Gene expression Gene Expression Regulation Genotype & phenotype healing Heart Heart attacks Heart failure Interferon Regulatory Factors - genetics Interferon Regulatory Factors - metabolism Internal Medicine IRF5 macrophage Macrophages - metabolism Medical sciences Mice Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - physiopathology myocardial infarction Myocardium - metabolism Myocardium - pathology Nanoparticles Phenotype RNA - genetics Rodents Studies Tissue engineering Transcription factors Ventricular Remodeling Wound healing heart failure IL lipidoid nanoparticle myocardial infarction interferon regulatory factor 5 macrophage siRNA TNF LNP healing MMP small interfering ribonucleic acid tumor necrosis factor fluorescence reflectance imaging tissue inhibitor of metalloproteinase myocardial infarction matrix metalloproteinase IRF5 FRI interleukin MI TIMP In vivo Improvement Phenotype Treatment Infarct Healing agent Cardiovascular disease Circulatory system Cardiology Transcription factor Cicatrization Macrophage
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