p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network

We report that p73 is expressed in multiciliated cells (MCCs), is required for MCC differentiation, and directly regulates transcriptional modulators of multiciliogenesis. Loss of ciliary biogenesis provides a unifying mechanism for many phenotypes observed in p73 knockout mice including hydrocephal...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 14; no. 10; pp. 2289 - 2300
Main Authors:	Marshall, Clayton B., Mays, Deborah J., Beeler, J. Scott, Rosenbluth, Jennifer M., Boyd, Kelli L., Santos Guasch, Gabriela L., Shaver, Timothy M., Tang, Lucy J., Liu, Qi, Shyr, Yu, Venters, Bryan J., Magnuson, Mark A., Pietenpol, Jennifer A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 15-03-2016 Elsevier
Subjects:	Animals Bronchioles - metabolism Bronchioles - pathology Cell Differentiation Cells, Cultured Cilia - metabolism Cilia - pathology Epithelial Cells - cytology Epithelial Cells - metabolism Epithelium - metabolism Epithelium - pathology Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Regulatory Networks Lung - cytology Lung - metabolism Lung - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Phosphoproteins - deficiency Phosphoproteins - genetics Phosphoproteins - metabolism RNA Interference Sequence Analysis, RNA Trachea - metabolism Trachea - pathology Trans-Activators - deficiency Trans-Activators - genetics Trans-Activators - metabolism Transcriptome Tumor Protein p73 - deficiency Tumor Protein p73 - genetics Tumor Protein p73 - metabolism
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